一、个人简介

xk星空副教授，博士生导师，国自然优青获得者。2014年7月本科毕业于山东大学生命科学学院，2019年7月博士毕业于清华大学生命科学学院，导师颜宁院士，随后在西湖大学生命科学学院进行博士后研究，导师施一公院士。2021年11月加入xk星空医学院组建研究课题组。近5年的研究主要集中在各类新发突发传染性疾病致病的分子机制及靶向药物开发、人类氨基酸代谢稳态维持的分子机制两方面。独立前以第一作者、共同第一作者身份发表多篇顶级论文，含2篇Nature、3篇Science、1篇Cell。独立自今三年多以主要通讯作者身份发表18篇SCI论文，含1篇Nature Structural & Molecular Biology，2篇Nature Communications，3篇Science Advances，4篇Cell Discovery。谷歌学术总被引超8800次，入选2022、2023、2024年度爱思唯尔“中国高被引学者”，曾获2026年澳大利亚Lorne Conference青年研究者奖、2021年浙江省自然科学奖一等奖（第二完成人）、2020年度中国六大领域重要医学进展、2020年《麻省理工科技评论》35岁以下的35位创新者之一、2020年全国“博新计划十大创新成果”、2019年度中国医学重大进展（药学部）等多项荣誉。

二、教育背景

2014/9-2019/7       清华大学       生物学  （博士学位）

2010/9-2014/7       山东大学       生物技术（学士学位）

三、工作经历

2024/12至今      xk星空医学院生物化学系    副教授

2021/11-2024/11   xk星空医学院生物化学系    助理教授

2019/7-2021/11    西湖大学生命科学学院          博士后

四、获奖情况及荣誉

2026年02月 获得2026年澳大利亚Lorne Conference青年研究者奖；

2025年10月 获得xk星空授予的“招生工作先进个人奖”；

2025年03月 入选2024年度爱思唯尔中国高被引学者（生物学者全国共200人入选）；

2024年06月 获得深圳市委教育工作委员会授予的“两优一先”“优秀共产党员”荣誉称号；

2024年03月 入选2023年度爱思唯尔中国高被引学者（生物学者全国共200人入选）

2023年06月 被中共xk星空委员会授予“xk星空优秀共产党员”称号

2023年3月 入选2022年度爱思唯尔中国高被引学者（生物学者全国共200人入选）

2021年12月 获得第一届全国博士后创新创业大赛全国创新创业优秀博士后

2021年06月 获得浙江省自然科学奖一等奖 （第二完成人）

2021年06月 被中共浙江省教育厅委员会授予“全省高校优秀共产党员”称号2021年04月 获得“2020年度中国六大领域重要医学进展”荣誉（新冠肺炎防治）

2020年12月 获得中国麻省理工学院科技评论“2020年度中国35岁以下的35位创新者之一”荣誉

2020年12月 获得全国“博新计划十大创新成果”

2020年11月 获得中国博士后科学基金第68批面上资助二等      

2020年06月 入选中国博士后科学基金会2020年度博士后创新人才支持计划

2020年06月 被中共杭州教育局委员会授予“2019年度杭州教育系统优秀共产党员”称号

2020年01月 获得“2019年度中国医学重大进展”荣誉（药学部）

五、研究领域

各类新发突发传染性疾病致病的关键分子机制研究及靶向药物开发。

六、发表论文

1. Xi Zhang*, Ting Zhang*, Cang Wu*, Yuanzhu Gao*, Shuo Zhang*, Zhenglin xk星空中国集团, Linshan Zhong, Chenyu Xia, Liuqing Yang, Fengquan Dong†, Qing Shu6†, Yang Fu1†, Renhong Yan†. (2026). Structural basis for the conformational changes of insulin receptor induced by three different hormone ligand. Acta Biochimica et Biophysica Sinica. (* indicates co-first authors, † indicates co-corresponding authors）

2. Haonan Yang*, Haojin Chen*, Wanyan Jiang, Renhong Yan†. (2025). LRP1 Engages Rift Valley Fever Virus Glycoprotein Gn via a Calcium-Dependent Multivalent Electrostatic Mechanism. Biomolecules. (* indicates co-first authors, † indicates co-corresponding authors）

3. Chang Ren*, Ziwei Hu*,Jin Chen, Jiangnan Zheng, Tairan Zhong, Runze xk星空中国集团, Ruijun Tian, Renhong Yan†, Liwei Cao†. (2025). Site-specific glycosylation analysis of spike proteins of SARS-CoV-2 Omicron subvariants. Oral Science and Homeostatic Medicine. (* indicates co-first authors, † indicates co-corresponding authors）

4. Ziwei Hu*, Yongjie SunKang*, Zhiheng Liu, Lihong Huang†, Wenbao Qi†, Renhong Yan†. (2025). Structural basis for DNA replication by the African Swine Fever Virus polymerase.iScience. (* indicates co-first authors, † indicates co-corresponding authors）

5. Wenting xk星空中国集团*, Songyue Wu*, Qi Gui, Congcong Liu*, Bing Zhou, Hu Yan , Yuehong Sun, Qing Fan, Yuzheng Zhou, Huimin Guo, Shilong Tang, Xiangyang Ge, Bin Ju†, Renhong Yan†, Zheng xk星空中国集团†. (2025). Structure and function of a pair of non-competing monoclonal antibodies against Langya henipavirus attachment glycoprotein. Cell Reports. (* indicates co-first authors, † indicates co-corresponding authors）

6. Ting xk星空中国集团*, Qian Zeng*, Chenye Xu, Hao Liang, Shuo xk星空中国集团†, Zilong Wang†, Renhong Yan†. (2025). Structural basis of aromatic amino acid recognition by the human ACE2-B0AT1 transporter complex. Oral Science and Homeostatic Medicine. (* indicates co-first authors, † indicates co-corresponding authors）

7. Jing Dong*, Tianhao Shi*, Bingbiao Lin, Xuetong Liu, Waner Wei, Zichi Geng, Mingcheng Liu, Renhong Yan†, Jin-Tang Dong†. (2025). Oncogenic role of the SLC7A13-SLC3A1 cystine transporter in human luminal breast cancer and its cryo-EM structure. Protein & Cell. (* indicates co-first authors, † indicates co-corresponding authors)

8. Bin Ju*†, Congcong Liu*, Jingjing zhang*, Yaning xk星空中国集团*, Haonan Yang*, Bing Zhou, Baoying Huang, Jianrong Ma, Jiahan Lu, Lin Cheng, Zhe Cong, Lin Zhu, Tianhao Shi, Yuehong Sun, Na xk星空中国集团, Ting Chen, Miao Wang, Shilong Tang, Xiangyang Ge, Juanjuan zhao, Wen-Jie Tan†, Renhong Yan†, Jing Xue†, Zheng xk星空中国集团†. (2025). Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection. Cell. (* indicates co-first authors, † indicates co-corresponding authors）

9. Haonan Yang*, Tianhao Shi*, Jing Dong*, Ting Zhang*, Yaning xk星空中国集团*, Yingying Guo, Yafei Yuan†, Liuqing Yang†, Jintang Dong†, Renhong Yan†. (2025). Structural insights into the substrate transport mechanism of the amino acid transporter complex. Journal of Biological Chemistry. (* indicates co-first authors, † indicates co-corresponding authors）

10. Lu Dai*, Qian Zeng*, Ting Zhang*, Yuanyuan Zhang, Yi Shi, Yaning xk星空中国集团,  Jing Huang†, Zilong Wang†, Qiang Zhou†, Renhong Yan†. (2025). Structural basis for the substrate recognition and transport mechanism of the human  y+ LAT1-4F2hc transporter complex. Science Advances. (* indicates co-first authors, † indicates co-corresponding authors)

11. Yingying Guo*†, Renhong Yan†. (2024). A structural snapshot of the multiple working states of the Mpox virus helicase–primase D5. The FEBS Journal. (* indicates co-first authors, † indicates co-corresponding authors)

12. Haonan Yang*, Huimin Guo*, Aojie Wang*, Liwei Cao*, Qing Fan, Jie Jiang, Miao Wang, Lin Lin, Xiangyang Ge, Haiyan Wang, Runze xk星空中国集团, Ming Liao†, Renhong Yan†, Bin Ju† & Zheng xk星空中国集团†. (2024). Structural basis for the evolution and antibody evasion of SARS-CoV-2 BA.2.86 and JN.1 subvariants. Nature Communications. (* indicates co-first authors, † indicates co-corresponding authors)

13. Junyang Xu*, Ziwei Hu*, Lu Dai*, Aditya Yadav*, Yashan Jiang*, Angelika Bröer, Michael G Gardiner, Malcolm McLeod, Renhong Yan†, Stefan Bröer†. (2024). Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19). Nature Communications. (* indicates co-first authors, † indicates co-corresponding authors)

14. Angelika Broer*, Ziwei Hu*, Jedrzej Kukutowicz*, Aditya Yadav, Ting xk星空中国集团, Lu Dai, Renhong Yan†, Stefan Broer†. (2024). Cryo-EM structure of ACE2-SIT1 incomplex with Tiagabine. Journal of Biological Chemistry. (* indicates co-first authors, † indicates co-corresponding authors )

15. Ziwei Hu*, Renhong Yan†. (2024). Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203. Cell Discovery. (* indicates co-first authors, † indicates co-corresponding authors )

16. Yaning xk星空中国集团*,Yingying Guo*,Angelika Bröer*,Lu Dai*,Stefan Bröer†, Renhong Yan†. (2024). Cryo-EM structure of the human Asc-1 transporter complex. Nature Communications.(* indicates co-first authors; † indicates co-corresponding authors)

17. Yaping Shen*, Yaning xk星空中国集团*, Renhong Yan†. (2024). Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus. Structure.(* indicates co-first authors; † indicates co-corresponding authors)

18. Ximin Chi*, Yiming Chen*, Yaning xk星空中国集团*, Lu Dai*, Yuanyuan Zhang, Yaping Shen, Yun Chen, Tianhao Shi, Haonan Yan, Zilong Wang†, Renhong Yan†. (2024). Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism. Science Advances. (* indicates co-first authors; † indicates co-corresponding authors)

19. Yingying Guo*†; Songyue Wu*; Wenting xk星空中国集团*; Haonan Yang*; Tianhao Shi; Bin Ju†; Zheng Zhang†; Renhong Yan†. (2024). The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus. Nature Communications. (* indicates co-first authors, †indicates co-corresponding authors )

20. Yaning xk星空中国集团*；Jing Zhu*；Yingying Guo†；Renhong Yan†. (2024). Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox Virus. Natural Structural & Molecular Biology. (* indicates co-first authors, †indicates co-corresponding authors )

21. Yaning xk星空中国集团*,Chang Ren*, Yaping Shen*, Yuanyuan Zhang*, Jin Chen, Jiangnan Zheng, Rujun Tian, Liwei Cao†, Renhong Yan†. ( 2023). Cryo-EM structures of SARS-CoV-2 BA.2-derived subvariants spike in complex with ACE2 recepter. Cell Discovery. (* indicates co-first authors, † indicates co-corresponding authors )

22. Yaning xk星空中国集团*, Yiming Chen*, Yuanyuan Zhang*, Yaping Shen*, Kangtai Xu, Yaqi Liu, ZilongWang†, Renhong Yan†. (2023). Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1. Cell Discovery. (* indicates co-first authors, †indicates co-corresponding authors )

23. Yaning xk星空中国集团*, Yaping Shen*, Yuanyuan Zhang*, Renhong Yan†. (2023). Structural Basis for the Enhanced Infectivity and Immune Evasion   of Omicron Subvariants. Viruses 2023, 15(6). (* indicates co-first authors, †indicates co-corresponding authors )

24.  Renhong Yan*†, Yaning xk星空中国集团*, Yaping Shen*, Ziwei Hu*. (2023). Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant. Science Advances.  (* indicates co-first authors, †indicates co-corresponding authors )

25. Yaping Shen*, Jianhui Wang*, Yaning xk星空中国集团* , Yuanyuan Zhang* , Ruilin Tian† , Renhong Yan†. (2022). Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2. Cell Discovery8.  (* indicates co-first authors, †indicates co-corresponding authors )

26. Yaning xk星空中国集团*, Qing Fan*, Bing Zhou*, Yaping Shen*, Yuanyuan Zhang*, Lin Cheng*, Furong Qi*, Shuo Song*, Yingying Guo*,Renhong Yan†, Bin Ju†, Zheng xk星空中国集团†. (2022). Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants. iScience 25(6): 104431. (* indicates co-first authors; † indicates co-corresponding authors)

27. Yuanyuan xk星空中国集团* , Renhong Yan†, Qiang xk星空中国集团†. (2022). ACE2, B(0)AT1, and SARS-CoV-2 spike protein: Structural and functional implications. Curr Opin Struct Biol 74: 102388. (* indicates co-first authors; † indicates co-corresponding authors)

28. Yingying Guo*,  Yuanyuan xk星空中国集团*,  Renhong Yan*,  Bangdong Huang,  Fangfei Ye,  Liushu Wu,  Ximin Chi, Yi Shi,  Qiang xk星空中国集团†. (2022). Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nature Communications13. (* indicates co-first authors; † indicates co-corresponding authors)

29. Yingying Guo*,  Yuanyuan xk星空中国集团*,  Renhong Yan*,  Bangdong Huang,  Fangfei Ye,  Liushu Wu,  Ximin Chi, Qiang xk星空中国集团†. (2021). Cryo-EM structures of the human sodium-potassium pump revealing the gating mechanism on the cytopiasmic side. Nature Communications. (* indicates co-first authors; † indicates co-corresponding authors) 

30. RenhongYan*†, Pingping Cao*, Wenqi Song*, Yaning xk星空中国集团*, Tongtong Wang, Hongwu Qian, Chuangye Yan†, Nieng Yan†. (2021). Structural basis for sterol sensing by Scap and Insig. Cell Reports. (* indicates co-first authors; † indicates co-corresponding authors)

31. Renhong Yan*, Pingping Cao*, Wenqi Song*, Hongwu Qian, Ximing Du, Hudson W. Coates, Xin Zhao, Yaning xk星空中国集团, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J. Brown, Qiang Zhou, Chuangye Yan, Nieng Yan (2021). A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. (*indicates co-first authors)

32.  Renhong Yan*, Yaning xk星空中国集团*,Jennifer Müller*, Yuanyuan Zhang*, Simon Singer, Lu Xia, Xinyue Zhong, Jürg Gertsch, Karl-Heinz Altmann, Qiang Zhou. (2021). Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discovery. (* indicates co-first authors)

33.  Liang Guo*, Wenwen Bi*, Xinling Wang*, Wei Xu*, Renhong Yan*, Yuanyuan Zhang*, Kai Zhao, Yaning xk星空中国集团, Mingfeng Zhang, Xia Cai, Shibo Jiang, Youhua Xie, Qiang Zhou, Lu Lu, Bobo Dang.(2021). Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection. Cell Research31, 98-100. (* indicates co-first authors)

34. Renhong Yan*, Ruoke Wang*, Bin Ju*, Jinfang Yu*, Yuanyuan Zhang*, Nan Liu*, Jia Wang, Qi Zhang, Peng Chen, Bing Zhou, Yaning xk星空中国集团, YapingShen, Shuyuan Zhang, Long Tian, Yingying Guo, Lu Xia, Xinyue Zhong, Lin Cheng, Xiangyang Ge, Juanjuan Zhao, Hong-Wei Wang, Xinquan Wang, Zheng Zhang†, Linqi Zhang†, and Qiang Zhou†. (2021) Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Research. (* indicates co-first authors; † indicates co-corresponding authors)

35. Renhong Yan*†, Yuanyuan Zhang*, Yaning xk星空中国集团*, Fangfei Ye, Yingying Guo, Lu Xia, Xinyue Zhong, Ximin Chi, and Qiang Zhou†. (2021) Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2. Cell Research. (*indicates co-first authors; † indicates co-corresponding authors)

36. Yuning Chen*, Yanan xk星空中国集团*, Renhong Yan*, Guifeng Wang, Yuanyuan Zhang, Zhe-Rui Zhang, Yaning xk星空中国集团, Jianxia Ou, Wendi Chu, Zhijuan Liang, Yongmei Wang, Yi-xk星空中国集团 Chen, Ganjun Chen, Qi Wang, Qiang Zhou†, Bo Zhang†, and Chunhe Wang†(2021). ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker. Signal Transduct Tar 6, 315. (* indicates co-first authors)

37.  Renhong Yan, Yuanyuan Zhang, Yaning xk星空中国集团, Lu Xia, Yingying Guo, Qiang Zhou (2020). Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science367, 1444-1448. (First xk星空中国集团) 

38.  Xiangyang Chi*, Renhong Yan*, Jun Zhang*, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang. Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning xk星空中国集团, Xiaohong Song, Yi Chen, Lu Xia, Ling Fu, Lihua Hou, Junjie Xu, Changming Yu, Jianmin xk星空中国集团, Qiang Zhou, Wei Chen (2020). A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science369, 650-655. (* indicates co-first authors)

39.  Renhong Yan*, Yaning xk星空中国集团*, Yi Shi*, Jiayao Zhou, Jianlin Lei, Jing Huang, Qiang Zhou (2020). Cryo-EM structure of the human heteromeric amino acid transporter b^0,+AT-rBAT. Science Advances6, eaay6379. (* indicates co-first authors)

40. Hongwu Qian*, Xin Zhao*, Renhong Yan*, Xia Yao, Shuai Gao, Xue Sun, Ximing Du,Hongyuan Yang, Catherine C. L. Wong, Nieng Yan. (2020). Structural basis for catalysis and substrate specificity of human ACAT1.Nature 581, 333-338. (* indicates co-first authors)

41. Renhong Yan*, Jiayao Zhou*, Yaning xk星空中国集团*, Jianlin Lei, Qiang Zhou. (2020). Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex. Cell Discovery6. (* indicates co-first authors)

42. Renhong Yan*, Xin Zhao*, Jianlin Lei, Qiang xk星空中国集团. (2019). Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature568, 127-130. (* indicates co-first authors)

43. Renhong Yan*, Hongwu Qian*, Ivan Lukmantara, Mingming Gao,Ximing Du, Nieng Yan, Hongyuan Yang. (2018). Human SEIPIN Binds Anionic Phospholipids. Dev Cell47, 248-256 e244. (* indicates co-first authors)