背景介绍

陈国安，xk星空医学院副教授，研究员，博士生导师。1986年毕业于西安交通xingkong星空中国官网医学院医疗系，1992年获西安交通xingkong星空中国官网医学院呼吸专业硕士学位。1999年获协和医科xingkong星空中国官网肿瘤学博士学位。1986至1996年其间就职于西安交通xingkong星空中国官网医学院第二附属医院呼吸内科，先后任住院医师和主治医师。2000年至2018年在美国密歇根xingkong星空中国官网(University of Michigan)医学院先从事肿瘤学博士后研究，以后历任讲师，研究助理教授和研究副教授。主要研究方向是肿瘤分子生物学，功能基因组学及生物信息学。应用高通量技术如蛋白质谱，基因表达芯片，单核苷酸突变（SNP）芯片，miRNA芯片以及核苷酸二代测序等研究肺癌组织及血中蛋白，RNA(包括miRNAs, lncRNA和circRNA)，及DNA的变化并探讨其在肿瘤发生发展中的作用及分子机理以及其在临床诊断，预后判断和治疗中的价值。作为项目主持人或主要成员承担过省,国家自然科学基金和美国国家或其他基金研究项目10余项。发表研究论文120余篇。作为第一作者或通讯作者有60余篇，作为第一作者的单篇论文最高引用超过千次，论文总引1万余次，h-index 57, i10-index 93(Google scholar 2025.01.01)。

工作经历

2018.10-今副教授，xk星空医学院

2017.09 - 2018.10 研究副教授，美国密歇根xingkong星空中国官网医学院

2010.09 - 2017.08 研究助理教授，密歇根xingkong星空中国官网医学院

2004.11 - 2010.08 讲师，密歇根xingkong星空中国官网医学院

2003.02 - 2004.10 Research Associate，密歇根xingkong星空中国官网医学院

1986.07 - 1996.08 住院医师/主治医师，西安交通xingkong星空中国官网xingkong星空中国官网第二附属医院

近6年发表论文：

1. Yu H, xingkong星空中国官网 Z, Ballman KV, Watson MA, Govindan R, Lanc I, Beer DG, Bueno R, Chirieac LR, Chui MH, xingkong星空中国官网 G, Franklin WA, Gandara DR, Genova C, Brovsky KA, Joshi MM, Merrick DT, Richards WG, Rivard CJ, Harpole DH, Tsao MS, van Bokhoven A, Shepherd FA, Hirsch FR. Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signature for Prognosis in Early-Stage Squamous Cell Lung Carcinoma. J Thorac Oncol. 2019 Jan;14(1):25-36. xingkong星空中国官网:10.1016/j.jtho.2018.09.006. PMID: 30253973.

2. Su W, Wang L, Niu F, Zou L, Guo C, Wang Z, Yang X, Wu J, Lu Y, Zhang J, Beer DG, Yang Z*, xingkong星空中国官网 G*. LINC00857 knockdown inhibits cell proliferation and induces apoptosis via involving STAT3 and MET oncogenic proteins in esophageal adenocarcinoma. Aging-US (Albany NY). 2019 May 13;11(9):2812-2821. xingkong星空中国官网:10.18632/aging.101953. PMID: 31085800

3. Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, xingkong星空中国官网 G, Kresty L, Kalyanaraman B, You M. Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. Nat Commun. 2019 May 17;10(1):2205. xingkong星空中国官网:10.1038/s41467-019-10042-1. PMID: 31101821.

4. Li L, Kang J, Zhang W, Cai L, Wang S, Liang Y, Jiang Y, Liu X, Zhang Y, Ruan H, xingkong星空中国官网 G, Wang M, Jia L.Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer. EBioMedicine. 2019 Jun 14. xingkong星空中国官网:10.1016/j.ebiom.2019.06.005 PMID: 31208947

5. Yang X, Zhang Q, Zhang M, Su W, Wang Z, Li Y, Zhang J, Beer DG, Yang S*, xingkong星空中国官网 G*. Serum microRNA Signature Is Capable of Early Diagnosis for Non-Small Cell Lung Cancer. Int J Biol Sci. 2019 Jun 10;15(8):1712-1722. xingkong星空中国官网: 10.7150/ijbs.33986. eCollection 2019. PMID: 31360113

6. Su W, Guo C, Wang L, Wang Z, Yang X, Niu F, Tzou D, Yang X, Huang X, Wu J, xingkong星空中国官网 X, Zou L, Yang Z*, xingkong星空中国官网 G*. LncRNAMIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling. Aging-US (Albany NY). 2019 Jul 10;11. xingkong星空中国官网: 10.18632/aging.102071. [Epub ahead of print] PMID: 31291201.

7. Yin Y, Xie CM, Li H, Tan M, xingkong星空中国官网 G, Schiff R, Xiong X, Sun Y. The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proc Natl Acad Sci U S A. 2019 Sep 23. pii: 201905973. xingkong星空中国官网: 10.1073/pnas.1905973116. [Epub ahead of print] PMID: 31548378.

8. Yang X, Su W, xingkong星空中国官网 X, Geng Q, Zhai J, Shan H, Guo C, Wang Z, Fu H, Jiang H, Lin J, Lagisetty KH, Zhang J, Li Y, Yang S, Massion PP, Beer DG, Chang AC, Ramnath N*, xingkong星空中国官网 G*.Validation of a serum 4-microRNA signature for the detection of lung cancer. Transl Lung Cancer Res. 2019 Oct;8(5):636-648. xingkong星空中国官网: 10.21037/tlcr.2019.09.11. PMID:31737499.

9. Yang X, Zhang Q, Su W, Zhang M, Shan H, Zhang J, xingkong星空中国官网 G, Guo C, Li Y. Expression level of serum miRNA-22 and its clinical significance in patients with lung cancer. International Journal of Respiration. 2019 Sep, 39(18), 1373-1378.

10. xingkong星空中国官网 X, Mao R, Su W, Yang X, Geng Q, Guo C, Wang Z, Wang J*, Kresty LA, Beer DG, Chang AC, xingkong星空中国官网 G*. Circular RNA circHIPK3 modulates autophagy via IR124-3p-STAT3-PRKAA/AMPKα signaling in STK11 mutant lung cancer. Autophagy. 2020 Apr;16(4):659-671. xingkong星空中国官网: 10.1080/15548627.2019.1634945. Epub 2019 Jun 28. PMID: 31232177

11. Jiang Y, Cheng W, Li L, Zhou L, Liang Y, Zhang W, xingkong星空中国官网 W, Wang S, Zhao H, xingkong星空中国官网 G, Zhou W, Ji G, Zhang Y, Hoffman RM, Wang M, Jia L. Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. Cell Biol Toxicol. 2020 Aug;36(4):349-364. xingkong星空中国官网: 10.1007/s10565-019-09503-6. Epub 2020 Jan 6. PMID:31907687.

12. Lyu X, Zeng L, Zhang H, Ke Y, Liu X, Zhao N, Yuan J, xingkong星空中国官网 G, Yang S.Hydroxychloroquine suppresses lung tumorigenesis via inducing FoxO3a nuclear translocation through STAT3 inactivation. Life Sci. 2020 Apr 1; 246:117366. xingkong星空中国官网: 10.1016/j.lfs.2020.117366. Epub 2020 Jan 28. PMID:32001266

13. Huang W, Ray P, Ji W, Wang Z, Nancarrow D, xingkong星空中国官网 G, Galbán S, Lawrence TS, Beer DG, Rehemtulla A, Ramnath N, Ray D. The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independent of its catalytic activity. J Biol Chem. 2020 May 1;295(18):5906-5917. xingkong星空中国官网: 10.1074/jbc.RA119.011869. Epub 2020 Mar 12. PMID:32165494.

14. Bueno R, Richards WG, Harpole DH, Ballman KV, Tsao MS, xingkong星空中国官网 Z, Wang X, xingkong星空中国官网 G, Chirieac LR, Chui MH, Franklin WA, Giordano TJ, Govindan R, Joshi MB, Merrick DT, Rivard CJ, Sporn T, van Bokhoven A, Yu H, Shepherd FA, Watson MA, Beer DG, Hirsch FR. Multi-institutional prospective validation of prognostic mRNA signatures in early stage squamous lung cancer (Alliance). J Thorac Oncol. 2020 Jul 24: S1556-0864(20)30558-X. xingkong星空中国官网: 10.1016/j.jtho.2020.07.005. Online ahead of print. PMID:32717408.

15. Sun S, He H, Ma Y, Xu J, xingkong星空中国官网 G, Sun Y, Xiong X. Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI. Cell Death Dis. 2020 Oct 13;11(10):852. xingkong星空中国官网: 10.1038/s41419-020-03082-9. PMID:33051438.

16. Su W, Wang L, Zhao H, Hu S, Zhou Y, Guo C, Wu B, Li L, Yang Z*, Beer DG, xingkong星空中国官网 G*. LINC00857 Interacting with YBX1 to Regulate Apoptosis and Autophagy via MET and Phosphor-AMPKa Signaling. Mol Ther Nucleic Acids. 2020 Oct 22;22: 1164-1175. xingkong星空中国官网: 10.1016/j.omtn.2020.10.025. eCollection 2020 Dec 4. PMID: 33312753. 

17. Xiao L,Li Y, Zeng X, Zhou Z, Hu S, Zhang S, Zhou Y, Zhang Z, Zhao H, Zhao H, Beer DG, Mao R*, xingkong星空中国官网 G*. Silencing of LOC389641 impairs cell proliferation and induces autophagy via EGFR/MET signaling in lung adenocarcinoma. Aging-US (Albany NY). 2020 Dec 9;12. xingkong星空中国官网: 10.18632/aging.202286. Online ahead of print. 2021,13(2), PMID:33318313 

18. Du C, Peng Y, He Y, xingkong星空中国官网 G, xingkong星空中国官网 H. Low levels of BRCA1 protein expression predict a worse prognosis in stage I-II colon cancer. Int J Biol Marker. 2021 Feb 14:1724600820986572. xingkong星空中国官网: 10.1177/1724600820986572. Online ahead of print. PMID:33583275

19. Xian J, Wang S, Jiang Y, Li L, Cai L, xingkong星空中国官网 P, Liu Y, Zeng X, xingkong星空中国官网 G, Ding C, Hoffman RM, Jia L, Zhao H, Zhang Y. Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma. Cancer Biol Med. 2021 Mar 18: j.issn.2095-3941.2020.0484. xingkong星空中国官网: 10.20892/j.issn.2095-3941.2020.0484. Online ahead of print. PMID:33733647

20. Yang X, Su W, Li Y, Zhou Z, Zhou Y, Shan H, Han X, Zhang M, Zhang Q, Bai Y, Guo C, Yang S*, Beer DG, xingkong星空中国官网 G*. MiR-22-3p suppresses cell growth via MET/STAT3 signaling in lung cancer. Am J Transl Res. 2021 Mar 15;13(3):1221-1232. eCollection 2021. PMID:33841651 

21. Robinson AD, Chakravarthi BVSK, Agarwal S, Chandrashekar DS, Davenport ML, xingkong星空中国官网 G, Manne U, Beer DG, Edmonds MD, Varambally S. Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma. Transl Oncol. 2021 May 25;14(8):101128. xingkong星空中国官网: 10.1016/j.tranon.2021.101128. Online ahead of print. PMID:34049151

22. Shi J, Lv X, Zeng L, Li W, Zhong Y, Yuan J, Deng S, Liu B, Yuan B, xingkong星空中国官网 Y, Ming Z, Yang X, Fang P, Yang S, xingkong星空中国官网 G. CircPVT1 promotes proliferation of lung squamous cell carcinoma by binding to miR-30d/e. J Exp Clin Cancer Res. 2021 Jun 10;40(1):193. xingkong星空中国官网: 10.1186/s13046-021-01976-w.PMID: 34112238

23. Gong L, Shu J, xingkong星空中国官网 X, Pan H, xingkong星空中国官网 G, Bi Y, Cui D, Li X, Liu D, Wang L, Wang Y, Liu P, Xiong X, Zhao Y. DEPTOR inhibits lung tumorigenesis by inactivating the EGFR-mTOR signals. Cancer Lett. 2021 Jul 25: S0304-3835(21)00356-6. xingkong星空中国官网: 10.1016/j.canlet.2021.07.031. Online ahead of print. PMID: 34320372

24. Liu W, Zhou Z, Li Y, Xu J, Shen Y, Luo S, Zhou Y, Wu X, Zhao H, Beer DG, He Y*, xingkong星空中国官网 G*. CSE1L silencing impairs tumor progression via MET/STAT3 signaling in lung cancer. Am J Cancer Res. 2021 Sep 15;11(9):4380-4393. eCollection 2021.PMID:3465989 

25. Song Y, Liang Y, Zou Q, Zeng S, Lin H, Liu M, Liu X, Du J, xingkong星空中国官网 G, Zou L, Su W, Niu F.J. LINC00857 promotes the proliferation of pancreatic cancer via MET, STAT3, and CREB. JGastrointest Oncol. 2021 Dec;12(6):2622-2630. xingkong星空中国官网: 10.21037/jgo-21-723.PMID:35070392

26. Li X, Zhang Z, Liu M, Fu X, A J, xingkong星空中国官网 G, Wu S, Dong JT. Establishment of a lncRNA-Based Prognostic Gene Signature Associated with Altered Immune Responses in HCC. Front Immunol. 2022 Apr 28;13:880288. xingkong星空中国官网: 10.3389/fimmu.2022.880288. eCollection 2022.PMID:35572559

27. Zhao H, Wang Y, Wu X, Zeng X, Lin B, Hu S, Zhang S, Li Y, Zhou Z, Zhou Y, Du C, Beer DG, Bai S*, xingkong星空中国官网 G*. FAM83A antisense RNA 1 (FAM83A-AS1) silencing impairs cell proliferation and induces autophagy via MET-AMPKɑ signaling in lung adenocarcinoma. Bioengineered. 2022 May;13(5):13312-13327. xingkong星空中国官网: 10.1080/21655979.2022.2081457. PMID:35635086

28. Lyu X, Zeng L, Shi J, Ming Z, Li W, Liu B, xingkong星空中国官网 Y, Yuan B, Sun R, Yuan J, Zhao N, Yang X, xingkong星空中国官网 G, Yang S.Essential role for STAT3/FOXM1/ATG7 signaling-dependent autophagy in resistance to Icotinib. J Exp Clin Cancer Res. 2022 Jun 11;41(1):200. xingkong星空中国官网: 10.1186/s13046-022-02390-6.PMID: 35690866

29. Qiao T, Yang W, He X, Song P, xingkong星空中国官网 X, Liu R, Xiao J, Yang X, Li M, Gao Y, xingkong星空中国官网 G, Lu Y, Zhang J, Leng J, Ren H. Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis. Cell Death Dis. 2023 Feb 13;14(2):117. xingkong星空中国官网: 10.1038/s41419-023-05626-1.PMID:36781833

30. Geng Q, Zhao H, Zhou Z, xingkong星空中国官网 X, Zhao H, xingkong星空中国官网 N, Li Y, Guo C, Yang A, Beer DG, xingkong星空中国官网 G*.CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma. Life Sci. 2023 Mar 7;320:121560. xingkong星空中国官网: 10.1016/j.lfs.2023.121560. Online ahead of print. PMID:36893940 

31. Carlos E M Relvas, Asuka Nakata, Guoan xingkong星空中国官网, David G Beer, Noriko Gotoh, Andre Fujita. A model-based clustering algorithm with covariates adjustment and its application to lung cancer stratification. J Bioinform Comput Biol. 2023 Sep 8;2350019. PMID: 37694488. xingkong星空中国官网: 10.1142/S0219720023500191

32. xingkong星空中国官网 S, Zhou Z, Li Y, Du Y, xingkong星空中国官网 G*.Application of single-cell sequencing to the research of tumor microenvironment. Front Immunol. 2023 Oct 27; 14:1285540. xingkong星空中国官网: 10.3389/fimmu.2023.1285540. eCollection 2023.PMID: 37965341 

33. Li Y, Du Y, Zhou Y, xingkong星空中国官网 Q, Luo Z, Ren Y, xingkong星空中国官网 X, xingkong星空中国官网 G*.Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death. Cell Commun Signal. 2023 Nov 16;21(1):327. xingkong星空中国官网: 10.1186/s12964-023-01267-1.PMID: 37974196 

34. Lin X, Shi Y, Zhan Y, Xing Y, Li Y, Zhou Z, xingkong星空中国官网 G*.Advances of Protein Palmitoylation in Tumor Cell Deaths. Cancers (Basel). 2023 Nov 21; 15(23): 5503. xingkong星空中国官网:10.3390/cancers15235503. PMID:38067206

35. Wu J, Huang X, Li X, Zhou H, xingkong星空中国官网 X, xingkong星空中国官网 Y, Guo Y, Huang J, Huang H, Huang Z, xingkong星空中国官网 G, Yang Z, Zhang J, Su W. Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A. Discov Oncol. 2024 Jan 2;15(1):3. xingkong星空中国官网: 10.1007/s12672-023-00855-4.PMID:38168833

36. Shi Y, Lin X, Wang J, Zhou Z, xingkong星空中国官网 S, xingkong星空中国官网 G*. The advances of HIF-1α/glycolysis axis in non-small cell lung cancer. Oncology Reports. Published online on February 15, 2024, https://xingkong星空中国官网org/10.3892/or.2024.8714 

37. Zhou Z, Li Y, xingkong星空中国官网 S, Xie Z, Du Y, Liu Y, Shi Y, Lin X, Zeng X, Zhao H, xingkong星空中国官网 G*. GLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma. Cell Commun Signal. 2024 Jun 3;22(1):303. xingkong星空中国官网: 10.1186/s12964-024-01678-8. PMID: 38831321 

38. Zeng X*, Yi Z, Zhang X, Du Y, Li Y, Zhou Z, xingkong星空中国官网 S, Zhao H, Yang S, Wang Y, xingkong星空中国官网 G*.Chromosome-level scaffolding of haplotype-resolved assemblies using Hi-C data without reference genomes. Nat Plants. 2024 Aug 5. xingkong星空中国官网: 10.1038/s41477-024-01755-3. Online ahead of print.PMID: 39103456

39. Zhao H, Wu X, Wang Y, Li X, Du Y, Zhou Z, Li Y, Liu Y, Zeng X, xingkong星空中国官网 G*. Histone variant H2AZ1 drives lung cancer progression through the RELA-HIF1A-EGFR signaling pathway. Cell Commun Signal. 2024 Sep 26;22(1):453. xingkong星空中国官网: 10.1186/s12964-024-01823-3. PMID: 39327549

40. Zhao H, Sun Y, Feng H, Cai J, Liu Y, Li Y, xingkong星空中国官网 S, Zhou Z, Du Y, Zeng X, Ren H, Su W, Mei Q, xingkong星空中国官网 G*.PFKP silencing suppresses tumor growth via the AXL-MET axis. Int J Biol Sci. 2024 Nov 11;20(15):6056-6072. xingkong星空中国官网: 10.7150/ijbs.100525. eCollection 2024. PMID: 39664584