SELF-INTRODUCTION：

I got my Ph.D from Northeast Normal University in 2013. My research interests focus on the molecular mechanism of tumor genesis and metastasis. EMT transcription factors (EMT-TFs) such as Snail1/Snail2, ZEB1/ZEB2, and Twist1/Twist2 have been shown to play a critical role in controlling EMT during embryogenesis and metastasis. Expression of EMT-TFs correlates with the tumor grade and nodal metastasis of many types of tumor and predicts a poor outcome in patients with metastatic xk星空官网. We are employing biochemical, molecular, and cellular approaches to study the functional regulation of EMT-TFs in breast xk星空官网 and, by discovery dis-regulations, to identify molecules that may serve as the therapeutic targets for metastasis prevention.

EDUCATION:

2008-2013: Ph.D. in Cell Biology, School of Life Science, Northeast Normal University, Changchun, China;

2004-2008: B.Sc. in Biology, School of Life Science, LangFang Normal College, Langfang, China.

WOKRING EXPERIENCE:

2021.01-till now: Research Assistant Professor, Southern University of Science and Technology, School of medicine

2017.04-2020.12: Associate Investigator, Shenzhen University, Health Science Center;

2014.10-2017.04: Postdoctor/Assistant Investigator, Shenzhen Institutes of Advanced Technology;

2014.05-2014.09: Instructor, Xuzhou Medical College;

2013.09-2014.03: Visiting Fellow, National xk星空官网 Insititute, Bethesda, USA;

HONORS AND AWARDS:

2017: The first prize of Science and Technology Award of Jilin Province (No. 4)

2015: Second prize of Natural Science Academic Achievements of Jilin Province (No. 4)

2015: Jilin province Excellent Doctoral Dissertation

2013: Doctoral scientific research first prize

2013: Excellent Graduated Graduate Student

2012-2013: Outstanding graduate student Scholarship, Northeast Normal University

2012-2013: Outstanding graduate student, Northeast Normal University

2012: Doctoral student National Scholarship, Ministry of Education

2011-2012: Outstanding graduate student Scholarship, Northeast Normal University

2009-2010: Outstanding graduate student Scholarship, Northeast Normal University

Research:

Molecular mechanism of tumor metastasis

PUBLICATIONS：

(1) Jianchao xk星空官网, Xinxin Lin, Liufeng Wu, Jia-Jia Huang, Wen-qi Jiang, Thomas Kipps, and Suping xk星空官网, Aurora B induces epithelial–mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis. Oncogene, 2020, 39(12):2550-2567.

(2) Jianchao xk星空官网, Ximing Shao, Haiyan Sun, Ke Liu, Zhihao Ding, Juntao Chen, Lijing Fang, Wu Su, Yang Hong, Huashun xk星空官网 and Hongchang xk星空官网, NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget, 2016, 7(38):61036-53.

(3) Jianchao xk星空官网, Qian Liang, Yang Lei, Min Yao, Lili Li, Xiaoge Gao, Jingxin Feng, Yu xk星空官网, Hongwen Gao, Dong-Xu Liu, Jun Lu, and Baiqu Huang, SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. xk星空官网 Research, 2012, 72(17):4597-608.

(4) Jianchao xk星空官网, Yang Lei, Xiaoge Gao, Qian Liang, Lili Li, Jingxin Feng, Yu xk星空官网, Baiqu Huang, and Jun Lu, p53 attenuates the oncogenic ras-induced epithelial-mesenchymal transition in human mammary epithelial cells. Biochemical and Biophysical Research Communications, 2013, 434(3):606-13.

(5) Suping xk星空官网, Han xk星空官网, Emanuela M. Ghia, Jiajia Huang, Liufeng Wu, Jianchao xk星空官网, Sharon Lam, Yang Lei, Jinsong xk星空官网, Bing Cui, George F. Widhopf II, Jian Yu, Richard Schwab, Karen Messer, Wenqi Jiang, Barbara A. Parker, Dennis A. Carson, and Thomas J. Kipps, Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. Proc Natl Acad Sci U S A, 2019, 116(4):1370-1377.

(6) Ximing Shao, Yi Liu, Qian Yu, Zhihao Ding, Wenyu Qian, Lei xk星空官网, Jianchao xk星空官网, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang xk星空官网 and Huashun xk星空官网, Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Research, 2016, 26(5):593-612.

(7) Qian Liang, Lili xk星空官网, Jianchao xk星空官网, Yang Lei, Liping Wang, Dong-Xu Liu, Jingxin Feng, Pingfu Hou, Ruosi Yao, Yu xk星空官网, Baiqu Huang, and Jun Lu, CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Scientific Reports. 2013, 14;3:2932.

(8) Jingxin Feng, Guiying Xu, Jiwei Liu, Na xk星空官网, Lili Li, Jiafei Ji, Jianchao xk星空官网, Lian xk星空官网, Guannan Wang, Xiuli Wang, Jiang Tan, Baiqu Huang, Jun Lu, Yu xk星空官网, Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer. Breast xk星空官网 Research and Treatment. 2016, 159(3):443-56.

(9) Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao xk星空官网, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei Wu, Xiaoqi Liu, Huashun xk星空官网, Rui Wang, Wu Su, and Hongchang xk星空官网, Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo. Molecular xk星空官网 Therapeutics, 2018, 17(5):988-1002.

(10) Ke Liu, Run Lei, Qiong xk星空官网, Xin-Xin Wang, Qian Wu, Peng An, Jianchao xk星空官网, Minyan Zhu, Zhiheng Xu, Yang Hong, Fudi Wang, Ying Shen, Hongchang xk星空官网, and Huashun xk星空官网, Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Scientific Reports. 2016, 16;6:21019.

(11) Ke Liu, Quan Lin, Yanxia Wei, Renbing xk星空官网, Ximing Shao, Zhihao Ding, Jianchao xk星空官网, Minyan Zhu, Lee S. Weinstein, Yang Hong, Hongchang xk星空官网, Huashun xk星空官网, Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neuroscience Letters. 2015, 597:97-103.

(12) Yu xk星空官网, Yanyan Gao, Guoping xk星空官网, Shuyan Huang, Zhixiong Dong, Chenfei Kong, Dongmei Su, Juan Du, Shan Zhu, Qian Liang, Jianchao xk星空官网, Jun Lu and Baiqu Huang, DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal xk星空官网 cells. International Journal of xk星空官网, 2011, 128:551-61.

(13) Dongmei Su, Xiue Peng, Shan Zhu, Ying Huang, Zhixiong Dong, Yu xk星空官网, Jianchao xk星空官网, Qian Liang, Jun Lu, Baiqu Huang, Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung xk星空官网 cells. Biochemical Journal, 2010, 433(2):333-43.

(14) Hanqing Shi, Hui Huang, Xitao xk星空官网, Jianchao xk星空官网, Xiutan Luo, Xiue Peng, Baiqu Huang, Jun Lu, c-Myc attenuates the ability of doxorubicin to reduce the colony formation partially through regulating Nbs1 in U2OS cells. Progress in Biochemistry and Biophysics, 2010, 37(8):855-63.