ACADEMIC

Jian xingkong星空中国官网, MD. PhD., is a Professor in Medical School of Southern University of Science and Technology (SUSTech). Dr xingkong星空中国官网 received his MD degree from Department of Medicine Tianjin Medical University, China, in 1986, and a Ph.D. in Pathology from the University of Michigan, Ann Arbor, Michigan, in 2001. After a three-year postdoctoral fellowship at the University of Michigan, Dr. xingkong星空中国官网 served as a tenure-track Assistant Professor at the University of Pittsburgh and the University of Michigan, Department of Internal Medicine and the University of Michigan Comprehensive Cancer Center. In 2011, his team returned to China and set up the 1st Center for Translational Medicine in Southwest of China. From 2011-2016, he serves as a professor and director for Key Laboratory of Longevity and Aging-related Diseases, Ministry of Education, China.  In 2016, he joined the SUSTech as the deputy director of medical school planning office.  His research interests have been focused on the study of aging-related diseases including aging-associated cancer biology. He has expertise in tumor microenvironment, chemoresistance and metastasis. He is the author/co-author of over 100 peer-reviewed publications and a reviewer for Department of Defense panel of cancer pathobiology, Cancer Research UK program, and Australia Prostate Cancer Research Program and Key Projects in National Science Foundation and “Changjiang Scholar” China.  From 2015 to 2017, he served as the associate editor for “Medical Oncology”.

EDUCATION

1981-1986: Bachelor, Department of Clinical Medicine, Tianjin medical university

1997-1998: Master, Old Dominion University & East Virginia Medical School, Immunology

1998-2001: Doctor, University of Michigan, Pathology

EXPERIENCE

1986.8-1995.1 Resident/Attending Doctor, Tianjin Third hospital/Tianjin Institute of Geriatrics

1995.1-1996.8 Visiting Scholar, Institute of Geriatrics, University of Wisconsin-Madison,  supporting by the fellowship of the World Health Organization

1996.8-1998.8 Visiting Research Scientist, Center for geriatric research at eastern Virginia medical school

1998.8-2004.6 PhD student/Researcher, University of Michigan school of medicine

2004.7-2010.12 Assistant Professor (Tenure track), school of medicine, university of Pittsburgh and university of Michigan

2011.1-2016. 7 Director/Professor, Key laboratory of longevity and geriatric diseases, Ministry of Education, school of translational medicine, Guangxi medical university,

2016.3- Adjunct Professor, university of Pittsburgh, school of medicine

2016.7- Professor, school of medicine, southern university of science and technology

RESEARCH INTERESTS

Translational research on discovery of tumor biomarkers and validation of xingkong星空中国官网 therapeutic targets

Chemoresistance, relapse and tumor metastasis

Aging and xingkong星空中国官网

HONORS AND AWARDS

2014-Experts with special government allowance from the state council

2013-National Talents Engineering, young and middle-aged experts with outstanding contributions

2013-International lecturer, Society for Basic Urology Research (SBUR)

2012-Outstanding national scientists and technicians

2011-Bagui Scholars of Guangxi Autonomous Region, counselor to the government of Guangxi Autonomous Region

2007-Mentoring Dr. Yi xingkong星空中国官网, Young Investigator Travel Award, ASBMR

2005-Mentoring Dr. Yi xingkong星空中国官网, Scholar-in-Training Award, AACR

2003-Scholar-in-Training Award, AACR

2003- Plenary Poster Award of 25^{xingkong星空中国官网} Annual Meeting of American Society for Bone and Mineral Research

2002-Alice L. Jee Memorial Young Investigator Award

2000-Plenary Poster Award of 22^{xingkong星空中国官网} Annual Meeting of American Society for Bone and Mineral Research

1994- Fellowship Award, World Health Organization (WHO)

BIBLIOGRAPHY

1. xingkong星空中国官网 J, Dai J, Qi Y, Lin D, Smith P, Strayhorn C, Mizokami A, Fu Z, Westman J, Keller ET. Osteoprotegerin inhibits prostate xingkong星空中国官网-induced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest. 107:1235-1244, 2001.

2. xingkong星空中国官网 J, Johnston G, Stebler B, Keller ET. Oxidative stress-mediated activation of NFkB and the interleukin-6 promoter requires NFkB-inducing kinase activity. Antioxidant & Redox Signaling. 3:493-504, 2001.

3. xingkong星空中国官网 J, Dai J, Lin D, Habib P, Smith P, Murtha J, Fu Z, Yao Z, Qi Y, Keller ET. Osteoprotegerin abrogates chronic alcohol ingestion-induced bone loss in mice. J Bone Miner Res 17:1256-1263, 2002.

4. xingkong星空中国官网 J, J Dai, Yao Z, xingkong星空中国官网 Y, Dougall W, Keller ET. Soluble RANK-Fc diminishes prostate tumor progression in bone. xingkong星空中国官网 Res. 63:7883-90, 2003

5. xingkong星空中国官网 J, xingkong星空中国官网 Y, Kitazawa R, Kitazawa S, Dai J, Qi W, Zhao X, Yao Z, Hall D, Keller ET. Bioluminescence imaging of RANK ligand transcriptional regulation in vivo. 59:360-9, 2004

6. xingkong星空中国官网 J, Dai J, xingkong星空中国官网 Y, Yao Z, O’Brein C, Qi W, Hall D, Ershler WB, Keller ET. In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging. Experimental Gerontology. 39:239-247, 2004

7. xingkong星空中国官网 Y, Cai Z, Galson DL, Xiao G, Liu YL, George D, Melhem MF, Yao Z and xingkong星空中国官网 J*. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate xingkong星空中国官网 growth and invasion. 66:1311-8, 2006

8. xingkong星空中国官网 Y, Cai Z, Xiao G, Keller ET, Mizokami A, Yao Z, Roodman GD, xingkong星空中国官网 J*. Monocyte chemotactic protein-1 (MCP-1) mediates prostate xingkong星空中国官网-induced bone resorption. xingkong星空中国官网 Res, 67:3646-53, 2007 (影响因子 6)

9. xingkong星空中国官网 Y, Cai Z, Xiao G, Liu Y, Keller ET, Yao Z, and xingkong星空中国官网 J*. CCR2 expression correlates with prostate xingkong星空中国官网 progression. J Cell Biochem. 101:676-685, 2007

10. xingkong星空中国官网 Y, Yao Z, and xingkong星空中国官网 J*. Prostate xingkong星空中国官网 bone metastasis: interaction between tumor cells and bone microenvironment. Chin J of Biochem and Molecul Biol, 23(3):167-171, 2007

11. xingkong星空中国官网 Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Yao Z, and xingkong星空中国官网 J*.PTHrP-induced MCP-1 production by human bone marrow endothelial cells promotes osteosteoclastast differentiation and prostate xingkong星空中国官网 cell proliferation and invasion in vitro.   Int J of xingkong星空中国官网. 121:724-733, 2007

12. xingkong星空中国官网 Y, Nie DB, Witt WT, Chen Q, Shen M, Xie H, Lai L, Dai Y, xingkong星空中国官网 J*. Expression of the fat-1 gene diminishes prostate xingkong星空中国官网 growth in vivo through enhancing apoptosis and inhibiting GSK-3β phosphorylation. Mol xingkong星空中国官网 Therapeutics, 7(10):3203-11, 2008

13. xingkong星空中国官网 Y, Wang J, Xu Y, Koch AE., Cai Z, Chen X, Galson DL, Taichman RS, and xingkong星空中国官网 J*. CXCL16 functions as a novel chemotactic factor for prostate xingkong星空中国官网 cells in vitro. Mol xingkong星空中国官网 Res, 6(4): 546-54, 2008

14. xingkong星空中国官网 Y, Chen QY, Corey E, Xie W, Fan J, Dai J, Mizokami A, and xingkong星空中国官网 J*. Activation of MCP-1/CCR2 axis promotes prostate xingkong星空中国官网 growth in bone. Clin Exp Metastasis, 26(2):161-9, 2009

15. Cai Z, Chen QY, Chen J, xingkong星空中国官网 Y, Xiao GZ, and xingkong星空中国官网 J*. MCP-1 promotes lung xingkong星空中国官网-induced bone resorptive lesions in vivo. Neoplasia, 11(3):228-236, 2009

16. xingkong星空中国官网 J, Patel L, and Pienta KJ. CC chemokine ligand 2 (CCL2) promotes prostate xingkong星空中国官网 tumorigenesis and metastasis. Cytokine Growth Factor Rev. 21(1):41-8, 2010

17. xingkong星空中国官网 J, xingkong星空中国官网 Y, and Pienta KJ. Multiple roles of CC chemokine ligand 2 (CCL2) in promoting prostate cancer growth. J Natl xingkong星空中国官网 Inst. 102(8):522-8, 2010

18. xingkong星空中国官网 J*, Sud S, Mizutani K, Gyetko MR, and Pienta KJ. Activation of urokinase plasminogen activator (uPA) and its receptor (uPAR) axis is essential for macrophage infiltration in a prostate xingkong星空中国官网 mouse model. Neoplasia 2011

19. xingkong星空中国官网 J, Patel L, Pienta KJ. Progress in Molecular Biolology: Translational Sciences. 2010;95:31-53.

20. Guo H, Yun C, Hou G, Du J, Huang X, xingkong星空中国官网 Y, Keller ET, xingkong星空中国官网 J*, Deng J*，Mangiferin attenuates Th1/Th2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model. Plos One. 9(6):e100394, 2014

21. Guo H, xingkong星空中国官网 Y, Wang J, Liu X, Keller ET, Liu Q, Zhou Q, xingkong星空中国官网 J*. Targeting Notch Signaling Pathway in xingkong星空中国官网 Therapeutics. Thoracic xingkong星空中国官网, 2014, 5; 473-86 (影响因子13)

22. Hongwei Guo, Xiaolin Zhou, Yi xingkong星空中国官网, Liye Xie, Qian Chen, Evan T. Keller, Qian Liu, Qinghua Zhou* , and xingkong星空中国官网 J*. Translational progress on tumor biomarkers. Thoracic xingkong星空中国官网. 27 JUL 2015, DOI: 10.1111/1759-7714.12294

23. Yu Zhu, Chunlin Zou, Zhe xingkong星空中国官网, Chaonan Qian, Xin Yang, Junlin Shi, Yudui Xia, xingkong星空中国官网 J*, Yi xingkong星空中国官网*. MEK inhibitor diminishes nasopharyngeal carcinoma (NPC) cell growth and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expression. Tumor Biology, 2015, 36(11):8811-8.

24. Sha He, Yi xingkong星空中国官网, Xia Liu, Xin Huang, Evan Keller, Chao-Nan Qian*, xingkong星空中国官网 J *; Wnt3a: function and implication in xingkong星空中国官网. Chinese Journal of xingkong星空中国官网, 2015, 34(3):50.

25. Lihui Wang, Yanli He, Weijun Liu, Shengbin Bai, Lei Xiao, Jie xingkong星空中国官网, Saravana M. Dhanasekaran, Zhuwen Wang, Shanker Kalyana-Sundaram, O. Alejandro Balbin, Sudhanshu Shukla, Yi Lu, Jules Lin, Rishindra M. Reddy, Philip W. Carrott, Jr., William R. Lynch, Andrew C. Chang, Arul M. Chinnaiyan, David G. Beer*, xingkong星空中国官网 J*, Guoan Chen*. Non-coding RNA LINC00535 promotes lung adenocarcinoma progression via the Akt pathway. Oncotarget, 7(10):11487-99，

26. Jing xingkong星空中国官网, Xin Yang, Hao Guan, Atsushi Mizokami, Evan T. Keller, Xiaozhen Xu, Xia Liu, Jiyong Tan, Longyuan Hu, Yi Lu*, xingkong星空中国官网 J*. Exosome-derived microRNAs contribute to prostate xingkong星空中国官网 chemoresistance. International Journal of Oncology, 2016, 49:838-846.

27. Yeguo Yang, Yi xingkong星空中国官网, Lihui Wang, Atsushi Mizokami, Evan T. Keller, xingkong星空中国官网 J*, Jiejun Fu*. Skp2 inhibition attenuates the resistance of prostate xingkong星空中国官网 cells to paclitaxel by up-regulation of p27. Oncology Reports, 2016, 36:559-566.

28. Yang Liu, Yi Chai, xingkong星空中国官网 J*, and Junwei Tang*. A function variant at miR-501 alters susceptibility thepatocellular carcinoma in a Chinese han population. Cell Physiol Biochem, 38(6):2500-8, 2016.

29. Qiuyan Chen, Siyuan Qin, Yang Liu, Minghuang Hong, Chao-Nan Qian, Evan T Keller, xingkong星空中国官网 J, xingkong星空中国官网 Y*. IGFBP-6 is a novel nasopharyngeal carcinoma prognostic biomarker. Oncotarget, 2016, Oct 18;7(42):68140-68150.

30. Yong Lei, Yanhua Yi, Yang Liu, Xia Liu, Evan T. Keller, Chao-Nan Qian, Jian xingkong星空中国官网* and xingkong星空中国官网 Y*. Metformin targets multiple signaling pathways in cancer. Chinese Journal of xingkong星空中国官网, 2017; 36(1):17.

31. H,H,H,Y,P,X,Y,X,ET,D*,J*, andJ*. Litchi seed extracts diminish prostate xingkong星空中国官网 progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling. . 2017; 7: 41656.

32. Wenchu Wang, Lihui Wang, Atsushi Mizokami, Junlin Shi, Chunlin Zou, Jinlu Dai, Evan T. Keller, Yi xingkong星空中国官网* and Jian xingkong星空中国官网*. Down-regulation of E-cadherin enhances prostate xingkong星空中国官网 chemoresistance via Notch signaling. Chinese Journal of xingkong星空中国官网, 2017; 36:35

33. Yutao Gao, Xia Liu, Ting xingkong星空中国官网, Luwei Wei, Antai Yang, Yi Lu, Jian xingkong星空中国官网, xingkong星空中国官网 xingkong星空中国官网, Sumei Wang and Fuqiang Yin. Cross-validation of genes potentially associated with overall survival and drug resistance in ovarian cancer. Oncology Reports. 2017; DOI: 10.3892/or.2017.5534

34. Jinlu Dai, Yi xingkong星空中国官网, Hernan Roca, Jill M. Keller, Jian xingkong星空中国官网, Laurie K. McCauley and Evan T. Keller. Immune mediators in the tumor microenvironment of prostate xingkong星空中国官网. Chinese Journal of xingkong星空中国官网, 2017; 36:29