Self-introduction

Dr. xingkong星空集团官网 SU is a Research Assistant Professor at School of Life Sciences, Southern University of Science and Technology. He did his Bachelor's at Jiangsu Ocean University and obtained a Ph.D. degree in biology at Nanjing Normal University. Then he moved to Shanghai Jiaotong University and Southern University of Science and Technology for post-doctorial studies. He is now interested in the functions of inositol phosphates and metabolic regulations of protein homeostasis. Dr. Su is supported by grants from the National Natural Science Foundation of China, the Department of Science and Technology of Guangdong Province, and the Shenzhen Science and Technology Innovation Commission. He has published several research papers in journals like Nature Chemical Biology, Molecular Cell, mBio, and FEBS Journal as first or co-first authors. 

Research Interests：

◆The Cullin-Ring ligases are the largest family of E3 enzymes that mediate 20% of proteasomal degradation. CRLs require neddylation, for optimal function and are tightly regulated by CSN deneddylase complex. Our group recently discovered a role for the glucose in assembling and disassembling CRL-CSN complexes. How such metabolite-dependent CRL regulation integrates into cellular physiology, is the emphasis.

Professional Experience：

◆ 2021.11~ Present, Research Assistant Professor, Department of neurobiology, SUSTech

◆ 2018.12~2021.07, Postdoctoral Fellow, Department of neurobiology, SUSTech

◆2016.07~2018.09, Postdoctoral Fellow, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine

Educational Background：

◆ 2011.09~2016.06 Ph. D., College of Life Sciences, Nanjing Normal University

◆ 2007.09~2011.06 Bachelor., College of Oceanography, Jiangsu Ocean University

Selected Publication：

◆Hongyun xingkong星空集团官网(#), Bobo xingkong星空集团官网(#), Yuebo Zhao(#), xingkong星空集团官网 SU(#), Yifan Peng, Xiaoli xingkong星空集团官网, Hongming Zhao, Hongyu Liu, Jie Feng, Hongjing Pei, Wenyong Zhang, Niu Huang, Kai Jiang, Masatoshi Ito, Guizhen Liu, Nicolas Jork, Karen E. Anderson, Li Zhao, Eiichiro Nagata8, Henning J. Jessen, Philip T. Hawkins, Changzheng Du, Feng Rao *. Oncometabolite 5-IP7 inhibits inositol 5-phosphatases to license E-cadherin endocytosis. Nature Chemical Biology. 2025 10.1038/s41589-025-02005-z.

◆xingkong星空集团官网 SU(#), Yifan Luo(#), Peitao Zhang, Hong Lin, Weijie Pu, Hongyun Zhang, Huifang Wang, Yi Hao, Yihang Xiao, Xiaozhe Zhang, Xiayun Wei, Siyue Nie,  Keren Zhang, Qiuyu Fu, Hao Chen, Niu Huang, xingkong星空集团官网 Ren, Mingxuan Wu, Billy Kwok Chong Chow, Xing Chen, Wenfei Jin, Fengchao Wang*, Li Zhao*, Feng Rao*, Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis, Molecular Cell, 2023 Jun 6;83(13):2316-2331. 

◆xingkong星空集团官网 SU(#), Jianhui Li(#), Wenting xingkong星空集团官网(#) Jinjing Ni, Rui Huang, Zuoqiang Wang, Sen Cheng, Yue Wang, Zhixin Tian, Qiuxiang Zhou, Donghai Lin, Wenjuan Wu, Christoph M. Tang, Xiaoyun Liu*, Jie Lu*, Yu-Feng Yao*, Methylation of PhoP by CheR regulates Salmonella virulence, mBio. 2021 Sep 21; e0209921. doi: 10.1128/mBio.02099-21.

◆xingkong星空集团官网 Y, xingkong星空集团官网 Y, Huang Y(*), Loss of ppr3, ppr4, ppr6 or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe, FEBS J, 2017, 284(2): 324-337. 

◆xingkong星空集团官网 Y(#), Chen C(#), Huang L(#), xingkong星空集团官网 J, Huang Y(*), Schizosaccharomyces pombe Homologs of Human DJ-1 Are Stationary Phase Associated Proteins That Are Involved in Autophagy and Oxidative Stress Resistance, PloS One, 2015, 10(12): e0143888.

◆Zhao Q(#), xingkong星空集团官网 Y(#), Wang Z(#), Chen C, Wu T, Huang Y(*), Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe, Bmc Evol Biol, 2014, 14: 86.

◆xingkong星空集团官网 Y, Chen J, Huang Y(*), Disruption of ppr3, ppr4, ppr6, or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe, FEMS Microbiol Lett, 2018 Aug 1;365(16).

◆Ren J(#), Sang Y(#), Qin R, xingkong星空集团官网 Y, Cui Z, Mang Z, Li H, Lu S, xingkong星空集团官网 J, Cheng S, Liu X, Li J, Lu J, Wu W, Zhao GP, Shao F, Yao YF(*), Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation, Emerg Microbes Infect, 2019;8(1):55-69.

◆Rao F(*), xingkong星空集团官网 H, xingkong星空集团官网 Y, Cullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and NewPhysiologic Players, Adv Exp Med Biol, 2020;1217:47-60.

◆Lin H(#), xingkong星空集团官网 X(#), Liu L(#), Fu Q, Zang C, Ding Y, xingkong星空集团官网 Y, Xu Z, He S, xingkong星空集团官网 X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T*, Rao F*, Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome, Proceedings of the National Academy of Sciences, 2020 Feb 25;117(8):4117-4124.

◆Xiaozhe xingkong星空集团官网, Shaodong Shi, xingkong星空集团官网 SU, Xiaoli xingkong星空集团官网, Sining He, Jing Wu, Jian Zhang, Feng Rao*, Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat, J Biol Chem, 2020 Jun 3;jbc.RA120.014375.

◆Jianhui Li(#), Shuting Liu(#), xingkong星空集团官网 SU, Jie Ren, Yu Sang, Jinjing Ni, Jie Lu, Yu-xingkong星空集团官网 Yao*, Acetylation of PhoP K88 is involved in regulating Salmonella virulence, Infect Immun, 2020 Dec 14;IAI.00588-20.

◆Hong Lin(#), Yuan xingkong星空集团官网(#), Yifan Luo(#), Wing xingkong星空集团官网 So(#), Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, xingkong星空集团官网 SU, Xiuyan xingkong星空集团官网, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang & Feng Rao*, IP6 -assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion against hyperinsulinemia, Nature Communications, 2021 Apr 28;12(1):2461.

◆Yifan Luo, xingkong星空集团官网 SU & xingkong星空集团官网 Rao*, Role of NEDD8 and neddylation dynamics in DNA damage response, Genome Instability & Disease, 2021, volume 2, pages139–149.

◆Zhenlei xingkong星空集团官网(#), Yufan Wu(#), Jinrong Fu(#), Xiujie Yu, xingkong星空集团官网 SU, Shikai Jia, Huili Cheng, xingkong星空集团官网 Shen, Xianghui He, Kai Ren, Xiangqian Zheng, Haixia Guan*, Feng Rao*, Li Zhao*. Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis. Nature Communications 2024 May 15;15(1):4108.