SELF-INTRODUCTION：
xk星空官网, Ph.D., Assistant Professor in the School of medicine, Southern University of Science and Technology. Dr. Wang graduated from Lanzhou University in 2011. He received his Ph.D from Lanzhou University in 2017. During the graduate study, he worked at Duke University as a visiting graduate student for 1 year. He had his postdoctoral training at Duke University. Dr. Wang’s research is focused on the molecular and cellular mechanism of pathological pain and itch, development of novel candidate analgesics and antipruritic. He has 34 publications, 10 of them are first author or co-corresponding author publications, including “Science Translational Medicine”、“Brain”、“Gastroenterology”、“Neuron” et al.. Dr. Wang has applied 7 patents in China and 3 PCTs and 1 patent in the United States.

EDUCATION:
2007.09 – 2011.06，BS in Biological Sciences, Lanzhou University
2011.09 – 2017.06，PhD, Lanzhou University
2016.01 – 2017.01，Visiting Graduate Student, Duke University
WOKRING EXPERIENCE:
2017.10 – 2021.01，Postdoctoral Research Associate, Duke University
2021.03 – present, Assistant professor, Southern University of science and technology
HONORS AND AWARDS:
2017 Excellent Graduate, Lanzhou University.
2015 National scholarship, Ministry of Education of the P. R. of China.

RESEARCH:
Our specific research interests are understanding mechanisms critical for xk星空官网 and itch and identifying new targets that modulate xk星空官网 and itch sensations. The long-term goal is developing powerful analgesics and anti-pruritics with limited side effects.
（1）Molecular and cellular mechanisms of xk星空官网 receptor signaling in health and disease;
（2）Development of novel candidate analgesics and antipruritics.
（3）Identify new targets for xk星空官网 and itch treatments;
（4）Neuro-immune interaction in xk星空官网 and itch;
（5）Molecular and cellular mechanism of pathological xk星空官网;

MANUSCRIPT REVIEWER AND EDITOR：
2017 - present Member, Society for Neuroscience
Reviewer：Neuroscience Bulletin, British journal of pharmacology, Biomedicine & Pharmacotherapy, Acta Dermato-Venereologica，Experimental and Therapeutic Medicine, Journal of Zhejiang University-SCIENCE B, Neuronscience letters, Molecular xk星空官网, Acta Biochimica et Biophysica Sinica, Nutrients, Journal of Nutritional Health & Food Science, Synapse, Peptides.

PUBLICATIONS：
1. Zilong Wang1, Changyu Jiang1, Qianru He, Megumi Matsuda, Qingjian Han, Kaiyuan xk星空官网, Sangsu Bang, Huiping Ding, Mei-Chuan Ko, Ru-Rong Ji*. Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. Science Translational Medicine. 2020; 12 (531): eaaw6471 (1: authors contributed equally to this work)
2. Zilong Wang1*, Changyu Jiang1, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Yul Huh, & Ru-Rong xk星空官网*. Central opioid receptors mediate morphine-induced itch and chronic itch. Brain. 2021 Mar 3;144(2):665-681(1: authors contributed equally to this work)
3. xk星空官网, Christopher R Donnelly, Ru-Rong Ji*. Scratching after Stroking and Poking: A Spinal Circuit Underlying Mechanical Itch. Neuron. 2019; 103: 952-954
4. Yong Chen1*, Zilong Wang1, Michele Yeo, Qiao-Juan xk星空官网, Ana E. López-Romero, Alan E. Medina-Arellano, Hui-Ping Ding, Xin xk星空官网, Qian Zeng, Sara L. Morales-Lázaro, Carlene Moore, Ying-Ai Jin, Johannes Morstein, Andrey Bortsov, Marcin Krawczyk, Frank Lammert, Anna Mae Diehl, Piotr Milkiewicz, Andreas E. Kremer, Jennifer Y. xk星空官网, Andrea Nackley, Tony E. Reeves, Mei-Chuan Ko, Ru-Rong Ji, Tamara Rosenbaum, Wolfgang Liedtke*. Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine. Gastroenterology. Accepted (1: authors contributed equally to this work)
5. xk星空官网, Jia-Xin Pan, Jing-Jing Song, Hong-Hai Tang, Hong-Ping Yu, Xu-Hui Li, Ning Li, Ting Zhang, Run Zhang, Meng-Na Zhang, Biao Xu, Quan Fang*, Rui Wang*. Structure-based optimization of multifunctional agonists for opioid and neuropeptide FF receptors with potent non-tolerance forming analgesic activities. Journal of Medicinal Chemistry. 2016, 59 (22), 10198-10208.
6. Sharat Chandra1, Zilong Wang1, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong xk星空官网, Andrey V. Bortsov. Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. Anesthesiology. 2020; In Press. (1: authors contributed equally to this work)
7. xk星空官网, Biao Xu, Changyu Jiang, Ting Zhang, Mengna Zhang, Ning Li, Qinqin Zhang, Kangtai Xu, Dan Chen, Jian Xiao, Quan Fang*. Spinal DN-9, a peptidic multifunctional opioid/neuropeptide FF agonist produced potent nontolerance forming analgesia with limited side effects. Journal of Pain, 2020, 21(3–4), 477−493
8. Zilong Wang1, Ning Li1, Pei xk星空官网, Hong-hai Tang, Zheng-lan Han, Jing-jing Song, Xu-hui Li, Hong-ping Yu, Ting Zhang, Run Zhang, Biao Xu, Meng-na Zhang, Quan Fang*, Rui xk星空官网*. Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance. Neuropharmacology. 2016; 108: 364-372 (1: authors contributed equally to this work)
9. Yang Suo, xk星空官网, Lejla Zubcevic, Allen L Hsu, Qianru He, Mario J Borgnia, Ru-Rong Ji, Seok-Yong Lee. Structural insights into electrophile irritant sensing by the human TRPA1 channel. Neuron, 2020; 105 (5), 882-894.e5
10. Christopher R Donnelly, Changyu Jiang, Amanda S Andriessen, Kaiyuan Wang, xk星空官网, Huiping Ding, Junli Zhao, Xin Luo, Michael S Lee, Yu L Lei, William Maixner, Mei-Chuan Ko, Ru-Rong Ji. STING controls nociception via type I interferon signaling in sensory neurons. Nature, 2021 Mar;591(7849):275-280.
11. Qingjian Han1, Di Liu1, Marino Convertino, xk星空官网, Changyu Jiang, Yong Ho Kim, Xin Luo, Xin Zhang, Andrea Nackley, Nikolay V Dokholyan, Ru-Rong Ji*. miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus. Neuron. 2018 Aug 8;99(3):449-463.e6. (1: authors contributed equally to this work)
12. Sangsu Bang1, Ya-Kai Xie1, Zhi-Jun Zhang1, xk星空官网, Zhen-Zhong Xu*, Ru-Rong Ji*. GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. J Clin Invest. 2018 Aug 1;128(8):3568-3582. (1: authors contributed equally to this work)
13. Sangsu Bang1, Christopher R. Donnelly1, Xin Luo1, Maria Toro-Moreno, Xueshu Tao, xk星空官网, Sharat Chandra, Andrey V. Bortsov, Emily R. Derbyshire, Ru-Rong Ji. Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. Nature Communications. 2021; 12(1):1704
14. Zilong Wang1, Quan Fang1, Zheng-lan Han, Jia-xin Pan, Xu-hui Li, Ning Li, Hong-hai Tang, Pei xk星空官网, Ting Zheng, Xue-mei Chang, Rui xk星空官网*. Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. Plos One, 2014; 9(8):e103773. (1: authors contributed equally to this work)
15. Jia-Xin Pan1, Zilong Wang1, Ning Li, Nan Zhang, Pei xk星空官网, Hong-Hai Tang, Ting Zhang, Hong-Ping Yu, Run Zhang, Ting Zheng, Quan Fang*, Rui xk星空官网*. Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice. European Journal of Pharmacology. 2015; 767(C):119-125. (1: authors contributed equally to this work)
16. Zheng-lan Han, xk星空官网, Xu-hui Li, Ning Li, Jia-xin Pan, Ting Zheng, Quan Fang*, Rui Wang*. Neuropeptide VF Enhances Cannabinoid Agonist WIN55,212-2-Induced Antinociception in Mice. Anesthesia & Analgesia. 2015, Nov;121(5):1360-8.
17. Zheng-lan Han, xk星空官网, Hong-zhu Tang, Ning Li, Quan Fang, Xu-hui Li, Xiong-li Yang, Xiao-yu Zhang, Rui Wang*. Neuropeptide FF attenuates the acquisition and the expression of conditioned place aversion to endomorphin-2 in mice. Behavioural Brain Research, 2013; 248(1):51-56.
18. Jia-Xin Pan, xk星空官网, Ning Li, Zheng-Lan Han, Xu-Hui Li, Hong-Hai Tang, Pei Wang, Ting Zheng, Quan Fang*, Rui Wang*. Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice. Neuroscience Letters, 2014, 578:187–191.
19. Ning Li1, Zhenglan Han1, xk星空官网, Yanhong Xing, Yulong Sun, Xuhui Li, Jingjing Song, Ting Zhang, Run Zhang, Mengna Zhang, Biao Xu, Quan Fang*, Rui Wang*. BN-9, a chimeric peptide with mixed opioid and NPFF receptors agonistic properties, produces nontolerance-forming antinociception in mice. British Journal of Pharmacology. 2016; 173(11): 1864-1880. (1: authors contributed equally to this work)
20. Yong Chen, Quan Fang, xk星空官网, Jennifer Y Zhang, Amanda S MacLeod, Russell P Hall, Wolfgang B Liedtke*. Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch. Journal of Biological Chemistry. 2016; 291:10252-10262
21. Li XH1, Lin ML1, xk星空官网, Wang P, Tang HH, Lin YY, Li N, Fang Q*, Wang R*. Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice. Neurogastroenterology&Motility. 2016; 28(6):891-9. (1: authors contributed equally to this work)
22. Zheng-lan Han1, Quan Fang1, xk星空官网, Xu-hui Li, Ning Li, Xue-mei Chang, Jia-xin Pan, Hong-zhu Tang, Rui Wang*. Antinociceptive effects of central administration of the endogenous cannabinoid receptor type 1 agonist VDPVNFKLLSH-OH [(m)VD-hemopressin(a)], an N-Terminally extended Hemopressin peptide. J Pharmacol Exp Ther, 2014, 348:316–323. (1: authors contributed equally to this work)
23. Quan Fang, Zheng-Lan Han, Ning Li, xk星空官网, Ning He, Rui Wang*. Effects of neuropeptide FF system on CB1 and CB2 receptors mediated antinociception in mice. Neuropharmacology, 2012; 62 (2): 855-864.
24. Wangsheng Sun, Liang Hong, Gongming Zhu, xk星空官网, Xiaojin Wei, Jingman Ni*, Rui Wang*. An organocatalytic michael−michael cascade for the enantioselective construction of spirocyclopentane bioxindoles: control of four contiguous stereocenters. Org. Lett. 2014, 16, 544−547.
25. Liu1, Yuan Wang1, Yanhong Xing1, Jing Yu, Hong Ji, Ming Kai, xk星空官网, Dan Wang, Yixin Zhang, Depeng Zhao, Rui WangDesign, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potent μ-opioid agonists. J Med Chem. 2013; 56 (7): 3102-14. (1: authors contributed equally to this work)
26. Biao Xu, Mengna Zhang, Xuerui Shi, Run Zhang, Dan Chen, Yong Chen, xk星空官网, Yu Qiu, Ting Zhang, Kangtai Xu, Xiaoyu Zhang, Wolfgang Liedtke, Rui Wang*, Quan Fang*. The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via mu and kappa opioid receptors. British Journal of Pharmacology. 2020; 177 (1), 93-109
27. Ting Zhang, Zhenglan Han, Xuerui Shi, Weidong Zhao, xk星空官网, Run Zhang, Biao Xu, Mengna Zhang, Qinqin Zhang, Jian Xiao, Hanwen Zhu, Ting Zheng, Quan Fang*. Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. Journal of neuroinflammation. 2019. 15 (1), 320
28. Chao Chen, Biao Xu, Xuerui Shi, Mengna Zhang, Qinqin Zhang, Ting Zhang, Weidong Zhao, Run Zhang, xk星空官网, Ning Li, Quan Fang*. GpTx-1 and [Ala5, Phe6, Leu26, Arg28] GpTx-1, two peptide NaV1.7 inhibitors: analgesic and tolerance properties at the spinal level. British journal of pharmacology. 2018 175 (20), 3911-3927
29. Xu-hui Li1, Ning Li1, xk星空官网, Jia-xin Pan, Zheng-lan Han, Xue-mei Chang, Hong-hai Tang, Pei Wang, Rui Wang*, Quan Fang*. The hypotensive effect of intrathecally injected (m)VD-hemopressin(α) in urethane-anesthetized rats. Peptides, 2014, 56:45–51. (1: authors contributed equally to this work)
30. Hong-ping Yu, Nan Zhang, Ting Zhang, xk星空官网, Ning Li, Hong-hai Tang, Run Zhang, Meng-na Zhang, Biao Xu, Quan Fang*, Rui Wang*.Activation of NPFF2 receptor stimulates neurite outgrowth in Neuro 2A cells through activation of ERK signaling pathway. Peptides. 2016 Sep 23;86:24-32.
31. Zhang T, Han ZL, Shi XR, Zhao WD, xk星空官网, Zhang R, Xu B, Zhang MN, Zhang QQ, Xiao J, Zhu HW, Zheng T, Fang Q*. Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation. Bioorganic & medicinal chemistry. 2019, 27 (4), 630-643
32. Run Zhang, Biao Xu, Meng-na Zhang, Ting Zhang, xk星空官网, Geng Zhao, Guang-hai Zhao, Ning Li, Quan Fang*, Rui Wang*. Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model. European journal of pharmacology. 2017 813, 122-129
33. Ting Zheng, Ting Zhang, Run Zhang, xk星空官网, Zheng-Lan Han, Ning Li, Xu-Hui Li, Meng-Na Zhang, Biao Xu, Xiong-Li Yang, Quan Fang*, Rui Wang*. Pharmacological characterization of rat VD-hemopressin (α), an α-hemoglobin-derived peptide exhibiting cannabinoid agonist-like effects in mice. Neuropeptides. 2017 63, 83-90
34. Ning Li1, Zheng-lan Han1, Quan Fang*, xk星空官网, Hong-zhu Tang, Hui Ren, Rui Wang*. Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behavioural Brain Research, 2012; 233(2): 428-433. (1: authors contributed equally to this work)