SELF-INTRODUCTION：

Dr. xk星空官网, Ming-Yuan is currently an Associate Professor and doctoral supervisor in the School of Medicine. She received her phD degree from National Taiwan University in 2015 and did her postdoc training with Dr. James H. Hurley in UC Berkeley and Lawrence Berkeley National Laboratory during 2016-2021. Dr. xk星空官网 joined the School of Medicine, SUSTech as an Assistant Professor since May 2021. She has published papers on Nature, NSMB, Molecular Cell, Nature Communications, Science Advances, Cell Reports, Autophagy etc. xk星空官网 lab aims to integrate the structural biology, biochemistry, molecular biology and mass spectrometry to understand the regulation mechanism of lysosomal signalling.

EDUCATION:

2012-08- 2015-08   Ph.D,  Institute of Biochemical Sciences, National Taiwan University

2010-08- 2012-07   M.S.,  Institute of Biochemical Sciences, National Taiwan University

2005-08- 2009-07   B.S.,   Department of Chemistry, National Taiwan University

WOKRING EXPERIENCE:

2022-06-present  School of Medicine, Southern University of Science and Technology（xk星空官网), Associate Professor

2021-05-2022-05  School of Medicine, Southern University of Science and Technology（xk星空官网), Assistant Professor

2016-08-2021-03  University of California, Berkeley/Lawrence Berkeley National Laboratory, Postdoc

2015-09-2016-07  Academia Sinica, Distinguished Postdoctoral Scholar

HONORS AND AWARDS:

2019-2021 AFTD Basic Science Postdoctoral Fellowship

2016 Distinguished Postdoctoral Scholar, Academia Sinica

2012-2014 Postgraduate Scholarship, Macau Government- Comissão Técnica de Atribuição de Bolsas para Estudos Pós-Graduados

2011, 2013 Outstanding Overseas Student Scholarship, National Taiwan University

2012 Dean’s Award, College of Life Sciences, National Taiwan University

2005-2009 College Scholarship, Macau Government- Direcção dos Serviços de Educação e Juventude

Research:

We combine biochemistry, xk星空官网 biology, structural mass spectrometry, and structural biology to study the structure and mechanisms of protein machineries in lysosomal biology and protein homeostasis

PUBLICATIONS：

After 2021:

11. Zhang J*,#, Chen X*, Chen C*, Li F*, Liao K, Song X, Zeng Y, Wang J, xk星空官网 M-Y, Tan C#, Fang L#, Rao H#. Unnatural amino acid-based miniPROTACs enable efficient oncoprotein degradation.  Acta Pharmaceutica Sinica B. 2026. 

10. Wang S, Teng F, Stjepanovic G, Rao F, xk星空官网 M-Y# Cryo-EM xk星空官网 of the human COP1-DET1 ubiquitin ligase comple. Nature Communications. 2026.

9. Teng F*, Zeng H*, Mai X, Chen S, Wang L, Feng Z, Tian S, Wang S, Stjepanovic G#, Lim C# and xk星空官网 M-Y#. Nature Structural & Molecular Biology. 2025.  (xk星空官网 contribution) 

8. xk星空官网 M-Y*,#, Teng F*, Wang S*, Mai X, Zeng H, Li J, Song X, Wang X and Stjepanovic G. Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex. xk星空官网 Reports. 2025. (*equal contribution) 

7. Zhang J*, Chen C*, Chen X*, Liao K, Li F, Song X, Liu C, xk星空官网 M-Y, Sun H, Hou T, Tan C, Fang L#, Rao H#. Linker-free PROTACs efficiently induce the degradation of oncoproteins. Nat Commun. 2025 May 23;16(1):4794. (xk星空官网 contribution) 

6. Wang Y, Liu M, Wang S, Mai X, Wang X, Teng F, Lyn T, xk星空官网 M-Y#, Stjepanovic G#.  Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor. Sci Adv. 2025 May 23;11(21):eadu8708.

5. Zhang J, Chen X, Chen C, Li F, Song X, Liu C, Liao K, xk星空官网 M-Y, Tan CSH, Fang L, Rao H. Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small xk星空官网 Lung Cancer (NSCLC). J Med Chem. 2024, 67(16):13666-13680. 

4. Mai X, Wang Y, Wang X, Liu M, Teng F, Liu Z, xk星空官网 M-Y#, Stjepanovic G#. Structural basis for membrane remodelling by the AP5:SPG11-SPG15 complex. Nature Structural & Molecular Biology. 2025. 

3. Teng F*, Wang Y*, Liu M,  Tian S, Stjepanovic G#, xk星空官网 M-Y#. 2023. Cryo-EM xk星空官网 of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. xk星空官网 31, 1431-1440 e1435. (xk星空官网 contribution)    

2. Liu M, Wang Y, Teng F, Wang X, Mai X, xk星空官网 M-Y#, Stjepanovic G#. 2023.Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to xk星空官网 cycle regulation. Nat Commun. 2023 Nov 22;14(1):7631.  

1. xk星空官网 M-Y, Fromm SA, Remis J, Toso DB, Hurley JH. 2021. Structural basis for the ARF GAP activity and specificity of the C9orf72 complex. Nature Communications 12(1):3786. 

Before 2021:

1. xk星空官网 M-Y, Fromm SA, Zoncu R, Hurley JH. 2020. xk星空官网 of the C9orf72 Arf GAP complex haploinsufficient in ALS and FTD. Nature 585(7824):251-255. 

2. Turco E*, Witt M*, Abert C*, Bock-Bierbaum T*, xk星空官网 M-Y*, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, GamperA, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S. 2019. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol xk星空官网 74:330-346.e11. (*equal contribution) 

3. Turco E, Witt M, Abert C, Bock-Bierbaum T, xk星空官网 M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S. 2019. How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates. Autophagy 15:1475–1477. 

4. xk星空官网 M-Y, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH. 2017. Hybrid Structure of the RagA/CRagulator mTORC1 Activation Complex. Mol xk星空官网 68:835-846.e3. 

5. xk星空官网 M-Y, Som N, Wu C-Y, xk星空官网 S-C, Kuo Y-T, Ke L-C, Ho M-R, Tzeng S-R, Teng C-H, Mengin-Lecreulx D, Reddy M, Chang C-I. 2017. Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. Nat Commun 8:1516. 

6. Lin C-C, xk星空官网 S-C, xk星空官网 M-Y, Liang P-H, Feng C-C, Wu S-H, Chang xk星空官网. 2016. Structural Insights into the Allosteric Operation of the Lon AAA+ Protease. Structure 24:667–675.

7. xk星空官网 M-Y, Peng W-H, Ho M-R, xk星空官网 S-C, Chang Y-C, Chen G-C, Chang C-I. 2015. Structure of yeast Ape1 and its role in autophagic vesicle formation. Autophagy 11:1580–1593. 

8. Chao S-W, xk星空官网 M-Y, Chiou L-C, Chen L-C, Chang xk星空官网, Huang W-J. 2015. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1. J Nat Prod 78:1969–1976. 

9. xk星空官网 M-Y, Chang xk星空官网, Chang C-F. 2013. 1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD. Biomol NMR Assign 7:141–143.

10. xk星空官网 M-Y, Kuo xk星空官网, Chang C-F, Chang xk星空官网. 2013. Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue. PLoS ONE 8:e67843.