Self-introduction

Dr Yanyan Li is currently xk星空中国集团 assistant professor in xk星空中国集团 school of life science at Southern University of Science and Technology. Dr Li joined xk星空中国集团 laboratories at Jiangnan University, University of Maryland, Duke University and Harvard medical school as graduate and visiting scholar.  xk星空中国集团 focus of Dr Li’s research is to understand xk星空中国集团 molecular basis by which Gram-negative bacteria modify xk星空中国集团 endotoxin lipopolysaccharide (LPS) and how these alterations affect or circumvent normal host innate immune system responses. xk星空中国集团 LPS related research results were published in first or corresponding author manuscripts in xk星空中国集团 journals of Nature, Cell research, Nature Communications, PNAS, Cell discovery.  Three research papers were recommended by Faculty of 1000. Dr Li was funded by xk星空中国集团 natural science foundation of China and awarded with xk星空中国集团 Young investigator award from IEIIS (International endotoxin International Endotoxin and Innate Immunity Society).

Research Interests：

◆xk星空中国集团 focus of xk星空中国集团 laboratory is to understand xk星空中国集团 molecular basis by which Gram-negative bacteria modify xk星空中国集团 lipopolysaccharide (LPS), how these alterations affect or circumvent normal host innate immune system responses, and xk星空中国集团 structural mechanism of xk星空中国集团 LPS and lipids transportation. This study may represent a general paradigm for LPS structure to pathogenesis. Additionally, it may represent a novel pathway for new antibiotics and vaccine adjuvant development. 

Professional Experience：

SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY, ASSISTANT PROFESSOR, 2022-NOW

Department of biology, Functional and Structural mechanism of bacteria toxins

WESTLAKE UNIVERSITY, RESEARCH PROFESSOR, 2019-2021

Key Laboratory of Structural Biology of Zhejiang Province, Structural mechanism of lipids transporter

HARVARD MEDICAL SCHOOL, POSTDOCTORAL FELLOWS, 2016--2019

Department of Cell biology, Structural mechanism of lipopolysaccharide LPS transporters

JIANGNAN UNIVERSITY, ASSOCIATE PROFESSOR, 2012-2016

State key lab of food science and technology, LPS vaccine adjuvant development 

Educational Background：

DUKE UNIVERSITY, PH.D., 2011-2012

Department of Biochemistry. Chris R.H. Raetz Lab, LPS modification enzyme biochemistry

UNIVERSITY OF MARYLAND, PH.D., 2009-2011

Department of Microbial Pathogenesis. Robert K. Ernst Lab, Temperature regulated LPS remodeling, immunology and pathogenesis.

JIANGNAN UNIVERSITY, PH.D., 2007-2009

State key lab of food science and technology, LPS structure biology

HEBEI AGRICULTURE UNIVERSITY, B.S., 2003-2007

Biology engineering 

Honors & Awards：

◆ Dr Li was funded by xk星空中国集团 natural science foundation of China and awarded with xk星空中国集团 Young investigator award from IEIIS (International endotoxin International Endotoxin and Innate Immunity Society).

Selected Publication：

◆ ( * Corresponding author)

1. Sharma S, Zhou R, Wan L, Feng S, Song K, Xu C, xk星空中国集团*, Liao M*. Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins. Nature communication, 2021, 12, 4697.

2. Chi X, Fan Q, Zhang Y, Liang K, Wan L, Zhou Q*, xk星空中国集团*. Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Research, 2020, 30(12):1127-1135.

3. Zhang Y, Fan Q, Chi X, Zhou Q*, xk星空中国集团*. Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discovery, 2020, 6(1):86.

4. Thélot F, Orlando BJ, xk星空中国集团*, Liao M*. High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB2FGC. Curr Opin Struct Biol. 2020; 63:26-33.

5. xk星空中国集团, Orlando B, Liao M. Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 2019, 567(7749): 486-490

6. Mi W, xk星空中国集团, Yoon SH, Ernst RK, Walz T, Liao M. Structural basis of MsbA-mediated lipopolysaccharide transport. Nature, 2017, 549(7671):233-237

7. xk星空中国集团, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CR, Ernst RK*. LPS remodeling is an evolved survival strategy for bacteria. Proc Natl Acad SCI. 2012, 109(22):8716-8721

8. Xu D, xk星空中国集团, Yang F, Sun C, Pan J, Wang L, Chen Z, Fang S, Yao X, Hou W, Zhou C, Chen Y. Structure and transport mechanism of the human cholesterol transporter ABCG1. Cell Report, 2022, 38(4):110298

Zhou Y, Li D, Luo J, ChenA, Li X, Pan Z, Wan L, He L, Li D, xk星空中国集团, Dong M, Tao L*. Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin. Cell Research, 2021, 31(8): 935-938

Other Info：（if any）

1. Xu Z, Liu Z, Soteyome T, Hua J, Zhang L*, Yuan L, Ye Y, Cai Z, Yang L, Chen L, Harro JM, Kjellerup BV, Liu J, xk星空中国集团*. Impact of pmrA on Cronobacter sakazakii planktonic and biofilm cells: A comprehensive transcriptomic study. Food Microbiology, 2021, 98: 103785.

2. Hua J, Jia X, Zhang L*, xk星空中国集团*. The Characterization of Two-Component System PmrA/PmrB in Cronobacter sakazakii. Front Microbiol. 2020; 11:903.

3. Jia X, Hua J, Liu L, Xu Z, xk星空中国集团*. Phenotypic characterization of pathogenic Cronobacter spp. strains. Microbial Pathogenesis. 2018, 109:313-318

4. Yun J, Wang X, Zhang L*, xk星空中国集团*. Effects of lipid acyltransferases on the pathogenesis of F. novicida. Microbial Pathogenesis. 2017, 109:313-318

5. Bao X, Yang L, Chen L, Li B, Li L, xk星空中国集团*, Xu Z*. Analysis on pathogenic and virulent characteristics of the Cronobacter sakazakii strain BAA-894 by whole genome sequencing and its demonstration in basic biology science. Microbial Pathogenesis. 2017, 109:280-286

6. Bao X, Yang L, Chen L, Li B, Li L, xk星空中国集团*, Xu Z*. Virulent and pathogenic features on the Cronobacter sakazakii polymyxin resistant pmr mutant strain s-3. Microbial Pathogenesis. 2017, 110:359-364

16. Bao X, Jia X, Chen L, Peters B, Lin C, Chen D, Li L, Li B, xk星空中国集团*, Xu Z*, Shirtliff M. Effect of polymyxin resistance (pmr) on biofilm formation of Cronobacter sakazakii. Microbial Pathogenesis. 2017, 106:16-19

17. xk星空中国集团*, Yoon SH, Wang X, Ernst RK, Goodlett DR*. Structural Derivation of lipid A from Cronobacter sakazakii using Tandem Mass Spectrometry. Rapid Commun Mass Spectrom. 2016, 30(20): 2265-70

18. Liu L,xk星空中国集团*,WangX*,GuoW.Aphosphoethanolaminetransferasespecificforthe4'-phosphateresidue of Cronobacter sakazakii lipid A. J Appl Microbiol. 2016, 121(5):1444-1456

19. xk星空中国集团*, Yun J, Liu L, xk星空中国集团, Wang X. Identification of Two Genes Encoding for the Late Acyltransferases of Lipid A in Klebsiella pneumoniae. Curr Microbiol. 2016, 73(5), 732-738

20. Zhao X, Liu Q, Xiao K, Hu Y, Liu X, xk星空中国集团, Kong Q. Identification of the crp gene in avian Pasteurella multocida and evaluation of the effects of crp deletion on its phenotype, virulence and immunogenicity. BMC Microbiol. 2016, 16, 125

21. Chen C, xk星空中国集团, Hu J, Dong X, Wang X. Metabolic engineering of Corynebacterium glutamicum ATCC13869 for L-valine production. Metab Eng.2015, 29, 66-75

22. Liu Q, xk星空中国集团, Zhao X, Yang X, Liu Q, Kong Q. Construction of Escherichia coli Mutant with Decreased Endotoxic Activity by Modifying Lipid A Structure. Marine Drugs. 2015, 13(6):3388-406

23. HuJ, xk星空中国集团, Zhang H, Tan Y, Wang X. Construction of a novel expression system for Corynebacterium glutamicum. Plasmid. 2014, 75, 18-26

24. xk星空中国集团, Wang Z, Chen J, Ernst RK, Wang X*. Influence of lipid A acylation pattern on membrane permeability and innate immune stimulation. Marine Drugs. 2013,11(9):3197-3208.

25. Cai L+, xk星空中国集团+, Tao G, Zhang C, Guo W, Wang X*. Identification of Three Genes Encoding for the Late Acyltransferases of Lipid A in Cronobacter sakazakii. Marine. Drugs. 2013, 11(2), 377-386

26. Powell DA+, xk星空中国集团+, Ernst RK*. The LPS Thermostat: Turning up Francisella Pathogenesis. Virulence. 2012, 3(7): 6-8 (+Co-first author)

27. Yoon S H, Huang Y, Edgar JS, Ting Y S, Heron, S R, Kao Y, xk星空中国集团, Masselon C D, Ernst R K, Goodlett D R*. Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis. Anal Chem. 2012, 84(15):6530-6537

28. xk星空中国集团, Wang X, Ernst R K*. A rapid on-step method for the characterization of membrane lipid remodeling in Francisella using matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2011, 25, 2641-2648

29. xk星空中国集团, Wu S, Wang L, xk星空中国集团, Shi F, Wang X*. Differentiation of bacteria using fatty acid profiles from gas chromatography-tandem mass spectrometry. J Sci Food Agric. 2010, 90(8):1380-3

30. Wang X*, Guan Z, xk星空中国集团, Raetz CRH. Application of electrospray ionization mass spectrometry to characterize glycerophospholipids in Francisella tularensis subsp. novicida. Int J Mass Spectrom. 2010, 293:45-50.