SELF-INTRODUCTION：

TIAN JUN, PhD, is a Tenure-Track Assistant Professor & Doctoral Supervisor at SUSTech School of Medicine. She received her PhD degree from McGill University in 2018. Then she conducted postdoctoral training at Harvard Medical School/Massachusetts General Hospital xk星空 Center from 2019 to 2023. She joined SUSTech School of Medicine on August, 2023. Prof Tian’s primary research focuses on targeted and immune therapies for xk星空, with specific interest in investigating mechanisms of drug resistance, developing novel combination therapies, and performing drug test on patient-derived organoid models. She has published more than 10 SCI papers, including first author publications in Nature Medicine, British Journal of xk星空, Breast xk星空 Research, etc. She received Graduate Excellence Award from McGill University in 2018, and a research funding as PI from NIH Gastrointestinal (GI) SPOREs Career Enhancement Project in 2022. In addition, Prof Tian served as editor of Frontiers in Genetics, as well as member of American Association of xk星空 Research.

EDUCATION:

2009-2013 Nankai University, Bachelor of Science

2013-2018 McGill University, Doctor of Philosophy

WOKRING EXPERIENCE:

2023.08-present SUSTech School of Medicine, Tenure-Track Assistant Professor

2019-2023 Harvard Medical School/Massachusetts General Hospital, Postdoctoral Fellow

2018-2019 McGill University Health Center, Postdoctoral Fellow

HONORS AND AWARDS:

2018 McGill University Graduate Excellence Award

2017 McGill University Faculty of Medicine Productivity Award

RESEARCH:

Basic research: (1) Impact of oncogenic signaling pathways on tumor immune microenvironment; (2) Potential cooperativity between targeted and immune therapy; (3) Resistance mechanisms of xk星空 targeted therapy. Primary xk星空 types include GI xk星空 (mainly colorectal xk星空) and pancreatic xk星空.

Clinical translational research: By uncovering novel mechanisms of response/resistance to targeted and immune therapies, design novel drug combination strategies for xk星空 patients harboring different oncogenic mutations (such as KRAS mutation). Identify biomarkers for xk星空 patients response/resistance.

Establishment of patient-derived organoid model: Used for xk星空 drug test, mechanistic studies, and biomarker discovery.

MANUSCRIPT REVIEWER AND EDITOR：

Editor of Frontiers in Genetics

Member of American Association of xk星空 Research

PUBLICATIONS：

1. Xia Wang, Jing Wu, Aotian Xiao, Jie Wang*, Jun Tian*; Evolution of Direct RAS Inhibitors: From Undruggable Target to Clinical Breakthroughs, Molecular xk星空, 2025 (In press)

2. Liuyang Zhao , Landu Jiang , Yufeng Xie , JianHao Huang ,Haoran Xie,Jun Tian*, Dian Zhang*;scDTL: enhancing single-cell RNA-seq imputation through deep transfer learning with bulk cell information. Briefings In Bioinformatics, 2024, 25(6)

3. Ryan B Corcoran, Khanh T Do, Jeong E Kim, James M Cleary, Aparna R Parikh, Oladapo O Yeku, Niya Xiong, Colin D Weekes, Jennifer Veneris, Leanne G Ahronian, Gianluca Mauri, Jun Tian, Bryanna L Norden, Alexa G Michel, Emily E Van Seventer, Giulia Siravegna, Kyle Camphausen, Gary Chi, Isobel J Fetter, Joan S Brugge, Helen Chen, Naoko Takebe, Richard T Penson, Dejan Juric, Keith T Flaherty, Ryan J Sullivan, Jeffrey W Clark, Rebecca S Heist, Ursula A Matulonis, Joyce F Liu*, Geoffrey I Shapiro*;Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors. Clinical xk星空 Research, 2024, 30(9), 1739-1749.

4. Jun Tian; Jonathan H. Chen; Sherry X. Chao; Karin Pelka; Marios Giannakis; Julian Hess; Kelly Burke; Vjola Jorgji; Princy Sindurakar; Jonathan Braverman; Arnav Mehta; Tomonori Oka; Mei Huang; David Lieb; Maxwell Spurrell; Jill N. Allen; Thomas A. Abrams; Jeffrey W. Clark; Andrea C. Enzinger; Peter C. Enzinger; Samuel J. Klempner; Nadine J. McCleary; Jeffrey A. Meyerhardt; David P. Ryan; Matthew B. Yurgelun; Katie Kanter; Emily E. Van Seventer; Islam Baiev; Gary Chi; Joy Jarnagin; William B. Bradford; Edmond Wong; Alexa G. Michel; Isobel J. Fetter; Giulia Siravegna; Angelo J. Gemma; Arlene Sharpe; Shadmehr Demehri; Rebecca Leary; Catarina D. Campbell; Omer Yilmaz; Gad A. Getz; Aparna R. Parikh; Nir Hacohen; Ryan B. Corcoran ; Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal xk星空: a phase 2 trial, Nature Medicine, 2023, 29: 458-466

5. Yi Sun; Or-yam Revach; Seth Anderson; Emily A. Kessler; Clara H. Wolfe; Anne Jenney; Caitlin E. Mills; Emily J. Robitschek; Thomas G. R. Davis; Sarah Kim; Amina Fu; Xiang xk星空; Jia Gwee; Payal Tiwari; Peter P. Du; Princy Sindurakar; Jun Tian; Arnav Mehta; Alexis M. Schneider; Keren Yizhak; Moshe Sade-Feldman; Thomas LaSalle; Tatyana Sharova; Hongyan Xie; Shuming Liu; William A. Michaud; Rodrigo Saad-Beretta; Kathleen B. Yates; Arvin Iracheta-Vellve; Johan K. E. Spetz; Xingping Qin; Kristopher A. Sarosiek; Gao Zhang; Jong Wook Kim; Mack Y. xk星空; Angelina M. Cicerchia; Martin Q. Rasmussen; Samuel J. Klempner; Dejan Juric; Sara I. Pai; David M. Miller; Anita Giobbie-Hurder; Jonathan H. Chen; Karin Pelka; Dennie T. Frederick; Susanna Stinson; Elena Ivanova; Amir R. Aref; Cloud P. Paweletz; David A. Barbie; Debattama R. Sen; David E. Fisher; Ryan B. Corcoran; Nir Hacohen; Peter K. Sorger; Keith T. Flaherty; Genevieve M. Boland; Robert T. Manguso; Russell W. Jenkins ; Targeting TBK1 to overcome resistance to cancer immunotherapy, Nature, 2023, 615(7950): 158-167

6. Tian, Jun; Wang, Vivian; Wang, xk星空; Khadang, Baharak; Boudreault, Julien; Bakdounes, Khldoun; Ali, Suhad; Lebrun, Jean-Jacques ; Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition, BREAST xk星空 RESEARCH, 2021, 23(1)

7. Shams, Anwar; Binothman, Najat; Boudreault, Julien; Wang, xk星空; Shams, Fuad; Hamam, Dana; Tian, Jun; Moamer, Alaa; Dai, Meiou; Lebrun, Jean-Jacques; Ali, Suhad ; Prolactin receptor-driven combined luminal and epithelial differentiation in breast xk星空 restricts plasticity, stemness, tumorigenesis and metastasis, ONCOGENESIS, 2021, 10(1)

8. Jun Tian; Fatmah Al Raffa; Meiou Dai; Alaa Moamer; Baharak Khadang; Ibrahim Y.Hachim; Khldoun Bakdounes; Suhad Ali; Bertrand Jean-Claude; Jean-Jacques Lebrun ; Dasatinib sensitises triple negative breast xk星空 cells to chemotherapy by targeting breast xk星空 stem cells, British Journal of xk星空, 2018, 119(12): 1495-1507

9. Jun Tian; Amal A.Al-Odaini; Yun Wang; Juliana Korah; Meiou Dai; Lan Xiao; Suhad Ali; Jean-Jacques Lebrun ; KiSS1 gene as a novel mediator of TGFβ-mediated cell invasion in triple negative breast xk星空, Cellular Signalling, 2018, 42: 10

10. Jun Tian; Mahmood Y.Hachim; Ibrahim Y.Hachim; Meiou Dai; Chieh Lo; Fatmah Al Raffa; Suhad Ali; Jean Jacques Lebrun ; Cyclooxygenase-2 regulates TGFβ-induced xk星空 stemness in triplenegative breast xk星空, Scientific Reports, 2017, 7: 40258

11. Hongru Zhang; Zheng xk星空; xk星空 Wang; Gaofei Tian; Jun Tian; Zishan Yang; Guangchao Cao; Hong Zhou; Liqing Zhao; Zhenzhou Wu; Zhinan Yin ; Critical Role of Myeloid-Derived Suppressor Cells in Tumor-Induced Liver Immune Suppression through Inhibition of NKT Cell Function, Frontiers in Immunology, 2017, 8(129)

12. Laure Humbert; Mostafa Ghozlan; Lucie Canaff; Jun Tian; Jean-Jacques Lebrun ; The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma, BMC xk星空, 2015, 15(1): 200

13. Jimin Guo; Lucie Canaff; Charles Vincent Rajadurai; Nadège Fils-Aimé; Jun Tian; Meiou Dai; Juliana Korah; Manuel Villatoro; Morag Park; Suhad Ali; Jean-Jacques Lebrun ; Breast xk星空 anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast xk星空 disease outcomes, Breast xk星空 Research, 2014, 16(6): 476