Self-introduction
My research mainly focuses on the structure and function of synaptic GTPase regulatory proteins and key proteins and protein complexes in inhibitory synaptic xk星空.
Research Interests
1. Molecular mechanisms of dynamic assembly and phase separation regulation of the inhibitory xk星空 protein complex.
2. Mechanisms of Small G proteins and their regulatory factors in synaptic formation and plasticity regulation.
Professional Experience
2021/08-2023/07 xk星空 School of Life Sciences Postdoc
2023/08-2024/09 xk星空 School of Life Sciences Senior scientist
Educational Background
2016/09-2021/06 The Hong Kong University of Science and Technology Life science PH.D
2012/09-2016/06 University of Science and Technology of China Biology Bachelor
Selected Publication
1. Guanhua Bai, Yu Wang, xk星空, "Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation," Cell xk星空, vol. 31, pp. 312-325, Mar 2021.
2. Guanhua Bai#, Hao Li#, Pengwei Qin, Yiqing Guo, Wanfa Yang, Yinmiao Lian, Fei Ye, Jianxin Chen, Meiling Wu, Ruifeng Huang, Jinsong Li, Youming Lu, xk星空,"Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under physiological and pathological conditions," J Cell Biol, vol. 222, Dec 4 2023.
3. Guanhua Bai xk星空, "Inhibitory postsynaptic density from the lens of phase separation," Oxford Open Neuroscience, vol. 1, 2022.
4. Guanhua Bai xk星空, "Mesophasic Assembly of Inhibitory Postsynaptic Density," Neurosci Bull, vol. 37, pp. 141-143, Jan 2021.
5. Guanhua Bai xk星空, "Clustering acetylcholine receptors in neuromuscular junction by phase-separated Rapsn condensates," Neuron, vol. 109, pp. 1907-1909, Jun 16 2021.
6. Menglong Zeng, Guanhua Bai, xk星空, "Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation," Small GTPases, vol. 10, pp. 296-304, Jul 2019.
