Faculty
Self-introduction
Professor Guozhi Xiao is an internationally renowned bone biologist. Dr. Xiao obtained his PhD degree in biochemistry and molecular biology from Peking University in 1994. He finished his post-doc training (1994-1998) and worked as a research scientist (1998-2005) at the University of Michigan Ann Arbor. In 2005, he assumed an independent faculty position as a tenure-track assistant professor at the University of Pittsburgh School of Medicine in 2005 and was promoted to the level of associate professor with tenure in 2011. In 2012, he joined Rush University Medical Center in Chicago and assumed a prominent academic position as the Falk Endowed Chair Professor of Biochemistry and served as the director of research of the department of biochemistry. He later joined the SUSTech as a tenured full professor and later became the chair of the biological department. Dr. Xiao is the director of the Center for Experimental Animals at SUSTech. Dr. Xiao has made several contributions to our understanding the molecular control of skeletal development and homeostasis. His work is reported in 155 SCI-indexed articles, many in high profile journals, such as Nature Aging, Journal of Clinical Investigation and Nature Communications etc., and 16 book chapters etc. He serves as a reviewer for the US National Science Foundation, the Italian Ministry of Health and the National Natural Science Foundation of China and sits on the editorial boards of the Journal of Bone and Mineral Research (JBMR) and the Journal of Biological Chemistry (JBC). Dr. Xiao’s research interests focus in the following areas: (1) to determine how osteoblast, osteoclast, and chondrocyte formation is controlled during skeletal development and homeostasis under physiological and pathological conditions; (2) to define the mechanisms that modulate bone angiogenesis; and more recently; (3) to study the roles of focal adhesion (FA) proteins in skeletal development and homeostasis. By working on these projects, Xiao laboratory has also maintained a focus on important medical issues involving bone –osteoarthritis, osteoporosis, and disc degeneration. Information obtained from these studies will enhance our understanding of these pathological processes.
Research Interests
My research focuses include: 1) mechanisms that control bone and cartilage development and homeostasis; 2) mechanisms of cancer bone metastases; 3) mechanisms that modulate bone angiogenesis during skeletal development and homeostasis; and 4) the role of cell adhesion molecules such as Kindlin-2 and migfilin in bone and cartilage. By working on these projects, I also maintain a focus on medical issues involving bone – osteoporosis, osteoarthritis and metastatic osteolytic lesions and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.
Educational background
1979-1984：Nanchang University School of Medicine, Bachelor Degree of Medicine.
1985-1988：Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Master Degree.
1991-1994： Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Ph.D.
Professional experience
2015-present: Chair, Department of Biology, Southern University of Science and Technology, Shenzhen
2013-present: Professor and Chair, Department of Biology, Southern University of Science and Technology, Shenzhen.
2011-2013: Associate professor, Director of Research, Ralph and Marian C. Falk Endowed Professor of Biochemistry of Rush University.
2005-2011: Assistant professor/Associate professor (with tenure), University of Pittsburgh School of Medicine.
1998-2005: Instructor/Research assistant professor, University of Michigan School of Dentistry (Ann Arbor).
1994-1998：Post doctor, University of Michigan School of Dentistry (Ann Arbor).
Honors & Awards
1998 ASBMR Young Investigator Award
2012 Outstanding Alumni, Beijing Medical University (Currently Peking University Health Sciences Center)
2013-present: Shenzhen Pengcheng Scholar
2017-present: Shenzhen Peacock Scholar
Professional Activities
Editorial Board Member:
2009-2015: Journal of Bone and Mineral Research (JBMR)
2010-present: Chinese Journal of Biochemistry and Molecular Biology
2011-present: Stem Cell Discovery
2013-present: Journal of Biological Chemistry (JBC)
2015-present: Chinese Journal of Family Planning
Selected Publications
From total 250 publications
1. Walke W,Xiao G, and Goldman D. A dual function activity-dependent, muscle-specific enhancer from rat nicotinic acetylcholine receptor d-subunit gene. J Neurobiol. 1996; 31(3): 359-369.
2. Walke W,Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor d-subunit promoter. J Neurosci. 1996; 16(11): 3641-3651.
3. Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11:1103-1113.
4. Xiao G, Wang D, Benson MD, Karsenty G, and Franceschi RT. Role of the a2 integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem. 1998; 273, 32988-32994.
5. Frendo JL,Xiao G, Fuches S, Franceschi RT, Karsentry G, and Ducy P. Functional hierarchy between two OSE2 elements in the control of osteocalcin expression in vivo. J Biol Chem. 1998; 273, 30509-30516.
6. Wang D, Christensen, K, Chawla, K, Xiao G, Krebsbach P. and Franceschi, RT. Isolation and characterization of MC3T3-E1 murine preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res. 1999; 14:893-903.
7. Benson MD, Aubin JE, Xiao G, Thomas PE, and Franceschi RT. Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Cbf/runt binding sites. J Bone Miner Res. 1999; 14:396-405.
8. Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1. J Biol Chem. 2000; 275, 4453-4459.
9. Benson MD, Bargeon JL, Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression. J Biol Chem. 2000; 275: 13907-13917.
10. Franceschi RT. Xiao G, Thomas PE, Jiang D, and Benson MD. Extracellular matrix regulation of osteoblast-specific gene expression: role of the a2b1 integrin and Osf2/Cbfa1. Chemistry and Biology of Mineralized Tissues: Connect Tissue Res. 2000;41 Suppl 1:249-254.
11. Ma PX, Zhang R, Xiao G, and Franceschi RT. Engineering new bone tissuein vitro on highly pore poly(-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res. 2001; 54:284-293.
12. Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277:36181-36187.
13. Zhao M,Xiao G, Berry J, Franceschi RT, Reddi A, and Somerman MJ. Bone Morphogenetic Protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002; 17:1441-1451.
14. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17:101-110.
15. Franceschi RT andXiao G. Regulation of osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003; 88:446-454.
16. Franceschi RT. Xiao G, Jiang D, Gopalakrishnan R, Yang S and Reith E. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation: Connect Tissue Res. 2003;44 Suppl 1:109-16.
17. xingkong星空中国官网 C, Koh AJ, Datta NS, Zhang J, Even ET, Xiao G, Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem. 2004; 279, 29121-29129.
18. Jiang D, Franceschi RT, Boules H, and Xiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene:requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337.
19. Xiao G*, Jiang D, Ge C, Zhao Z, Yumei Lai, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, and Franceschi RT. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem. 2005; 280:30689-30696.
20. Roca H, Phimphilai M, Gopalakrishnan R,Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem. 2005; 280:30845-30855.
21. Zhao Z, Zhao M, Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitroandin vivo. Mol Ther. 2005; 12(2):247-53.
22. Lu, Y, Cai Z, Galson DL, Xiao G, Liu, Y, George DE, Melhem MF, Yao Z, Zhang J. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate. 2006; 66(12): 1311-8.
23. Franceschi RT, Xiao G. Osteoblasts: Staying the course. Meeting report from the 29th Annual Meeting of the American Society for Bone and Mineral Research. BoneKEy-Osteovision 2006; 4 (12), 327-332.
24. Zhu J, Jia X, Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases. J Biol Chem.2007; 282(37): 26656-64.
25. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 2007; 1116:196-207.
26. Lu Y,Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrP-induced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis. Int J Cancer. 2007; 121(4): 724-733.
27. Lu Y, Cai Z, Xiao G, Liu Y, Keller E, Yao Z, and Zhang J. CCR2 expression correlates with prostate cancer progression. J Cell Biochem. 2007; 101(3): 676-85.
28. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. Cancer Res. 2007; 67(8): 3646-53.
29. Ge C,Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007; 176(5): 709-818. PMCID: PMC2064027.
30. Feng, R, Anderson G, Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-kB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood. 2007; 109(3): 2130-2138.
31. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology. 2008; 149(4): 1960-8. PMCID: PMC2276723.
32. Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J, Xiao G. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells. J Cell Biochem. 2008 Feb 1;103(2):434-46. xingkong星空中国官网: 10.1002/jcb.21411.PMID: 17516572。
33. xingkong星空中国官网 D,Xiao G, Zhang M, Xing L, and Jonason JH. Post-translational regulation of Runx2 in bone cells. J Dent Res. 2008; 88(8): 693-703.
34. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs. 2009;189(1-4):144-152.
35. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J Biol Chem. 2008; 283(9): 5542-53. PMCID: PMC2736298.
36. Zhang X, Yu S, Galson, DL, Luo M, Fan J, Zhang J, Guan Y, Xiao G. Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. J Cell Biochem. 2008; 105(3): 885-95. PMCID: PMC2704124.
37. Liu Y, Yuan Y, xingkong星空中国官网 Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson M, Fan J. Interacting neuro-endocrine, innate, and acquired immune pathways regulate neutrophil from bone marrow following hemorrhage shock. J Immnol.2009;182(1):572-580. PMCID: PMC2610356.
38. Cai, Z, xingkong星空中国官网 Q, xingkong星空中国官网 J, Lu Y, Xiao G, Wu Z, Zhou Q, Zhang J. Monocyte chemotactic protein-1 promotes lung cancer-induced bone resorptive lesion in vivo. Neoplasia. 2009;11(3):228-36. PMCID: PMC2647725.
39. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC2762317. (This paper was listed as the "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy. BoneKEy is published by the International Bone & Mineral Society).
40. Ge C,Xiao G (co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC2781667.
41. xingkong星空中国官网 Y, Xiang M, Yuan Y, Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC2803625.
42. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD, Xiao G. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010 Aug 2;120(8):2755-66. PMCID: PMC2912190.
43. Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK, Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice. J Clin Invest. 2010 Nov 1;120(11):3901-11. PMCID: PMC2964981.
44. Xiang M, Yin L, xingkong星空中国官网 Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol. 2011 Mar;44(3):333-40. PMCID: PMC3095934.
45. Yang S, Xu H, Yu S, Cao H, Jie Fan, Ge C, Fransceschi RT, Dong HH, Xiao G. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem. 2011; 286(21):19149-58. PMCID: PMC3099728.
46. Xiang M, Shi X, xingkong星空中国官网 Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immnol.2011; 187(9) :4809-17, PMCID: PMC3197874.
47. Danciu TH, xingkong星空中国官网 Y, Koh A, Xiao G, McCauley LK, Franceschi RT. The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts. J Cell Biochem. 2011;113(1):70-9. PMCID: PMC3414260.
48. D'Souza S, Del Prete D, Jin S, Sun Q, Huston AJ, Kostov FE, Sammut B, Hong CS, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Grimes HL, Roodman GD, Galson DL. Gfi-1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease. Blood. 2011;118(26):6871-80. PMCID: PMC3245209.
49. Tang W, Yang F, xingkong星空中国官网 Y, de Crombrugghe B, Jiao H, Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8. PMCID: PMC3265850.
50. Xiang M, Yuan Y, Fan L, xingkong星空中国官网 Y, xingkong星空中国官网 A, Yin L, Scott MJ, Xiao G, Billiar TR, Wilson MA, Fan J. Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock. Shock. 2012 May;37(5):518-523. PMCID: PMC3328610.
51. xingkong星空中国官网 X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Kc R, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul;113(7):2532-42. PMCID: PMC3349778.
52. Xiao G*, Cheng H, Cao H, xingkong星空中国官网 K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, xingkong星空中国官网 D, xingkong星空中国官网 J, Wu C*. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC3375566.
53. Ellman MB, Kim JS, An HS, Chen D, Ranjan KC, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, xingkong星空中国官网 X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disc homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 1;505(2):283-90, PMCID: PMC3518428.
54. Yan D, xingkong星空中国官网 D, Xiao G, van Wijnen A, Im HJ. Bovine lactoferricin, an antimicrobial peptide, is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb;228(2):447-56, PMCID: PMC3463726.
55. Meng M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, xingkong星空中国官网 D. Chondrocyte BMP-2 Signaling Plays a Critical Role in Bone Fracture Healing. Gene. 512 (2013) 211–218. PMCID: PMC3531824.
56. Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, xingkong星空中国官网 D, Wang Q, Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis. Gene. 513 (2013) 101–110. PMCID: PMC3514579.
57. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, xingkong星空中国官网 D, Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-266. PMCID: PMC3596711.
58. Xu P, Wen Z, Shi X, xingkong星空中国官网 Y, Fan L, Xiang M, xingkong星空中国官网 A, Scott MJ, Xiao G, xingkong星空中国官网 S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction. J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC3646900.
59. Kim JS, Ellman MB, Yan D, An HS, Kc R, xingkong星空中国官网 X, Chen D, Xiao G, Cs-Zabo G, Hoskin DW, Buechter DD, van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep;228(9):1884-96. PMCID: PMC3703102.
60. Ellman MB, Kim J, An HS, Chen D, Kc R, xingkong星空中国官网 X, Xiao G, Yan D, Suh J, van Wijnen A, Wang J, Kim S, Im H. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene.2013 Jul 25;524(2):282-91. PMCID: PMC3679319.
61. Liu Z, Jiang Y, xingkong星空中国官网 Y, Wang J, Fan L, Scott MJ, Xiao G, xingkong星空中国官网 S, Billiar TR, Wilson MA, Fan J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation. J Immunol. 2013 Jul 15;191(2):857-64. PMCID: PMC3702632.
62. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, xingkong星空中国官网 D, Yao Z, Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013 Aug 21;9(8):830-41. PMCID: PMC3753447.
63. Xiao G*, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH*. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice. J Biol Chem. 2013 Aug 30;288(35):25350-61. PMCID: PMC3757199.
64. Zhu K, Jiao H, xingkong星空中国官网 S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res.2013;28: 1870–1884. PMID: 23649506. This is an EDITOR'S CHOICE paper of September 2013 JBMR issue and highlighted with a Commentary paper ( Schipani et xingkong星空中国官网. J Bone Miner Res. 2013;28:1866-1869. xingkong星空中国官网: 10.1002/jbmr.2045).
65. Cao H, Zhu K, Qiu L, xingkong星空中国官网 S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC3798504.
66. Yan D, Kc R, xingkong星空中国官网 D, Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: 24036113.
67. Wang B, Jin H, Zhu M, xingkong星空中国官网 J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, xingkong星空中国官网 D Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast differentiation. Arthritis Rheumatol. 2014 Jan;66(1):107-20. xingkong星空中国官网: 10.1002/art.38195. PMID: 244312822.
68. xingkong星空中国官网 TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, xingkong星空中国官网 D, O'Keefe RJ. BMP-2 regulates chondrocyte differentiation through modulation of COX-2 and ATF4. Osteoarthritis Cartilage. 2014 Mar;22(3):481-9. PMID: 24418675.
69. xingkong星空中国官网 S, Shu B, Zhang Y, xingkong星空中国官网 J, Guo J, Wang Y, Ren F, Xiao G, Chang Z, xingkong星空中国官网 D. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. Arthritis Rheumatol. 2014 Jul;66(7):1854-63. xingkong星空中国官网: 10.1002/art.38521. PMID: 24578159.
70. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, xingkong星空中国官网 Y, Scott MJ, Xiao G, xingkong星空中国官网 S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014 Aug;21(8):1229-39. PMID: 24769733. PMCID: PMC4085529.
71. Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem. 2014 Nov 7;289(45):31001-13. PMID: 2523719.
72. Wen Z, Fan L, xingkong星空中国官网 Y, Zou Z, Scott MJ, Xiao G, xingkong星空中国官网 S, Billiar TR, Wilson MA, Shi X, Fan J. Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation. J Immunol. 2014 Nov 1;193(9):4623-33. PMID: 25267975.
73. Niu NK, Wang ZL, Pan ST, Ding HQ, Au GHT, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, xingkong星空中国官网 XW, Qiu JX, Zhou SF. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther. 2015 Mar 12;9:1555-84. PMID: 25792811.
74. Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, xingkong星空中国官网 D, Zhou J, Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy. J Biol Chem. 2015 Mar 27;290(13):8081-94. xingkong星空中国官网: 10.1074/jbc.M114.603985. Epub 2015 Feb 3. PMID: 25648889.
75. Wu C, Jiao H, Lai Y, Zheng W, xingkong星空中国官网 K, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, xingkong星空中国官网 J, xingkong星空中国官网 D, Xiao G. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 7;6:7531. xingkong星空中国官网: 10.1038/ncomms8531. PMID: 26151572..
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198. Chen M, Chen S, Xie C, xingkong星空中国官网 F, Tao C, Gong W, Qu M, Lin S, Shao Z, Xiao G. J Orthop Translat. 2026 Jan 8;56:101029. xingkong星空中国官网: 10.1016/j.jot.2025.11.005. eCollection 2026 Jan. PMID: 41836571
199. Qin H, Yu J, Yu H, Zhou C, Yuan D, Wang Z, Zhu Z, Wei G, Ou P, xingkong星空中国官网 Z, Jiang H, Shen J, Xiao G, Bai X, Wang H, Zhang HT, Speakman JR, xingkong星空中国官网 D, Tong L. Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism. Cell Metab. 2026 Mar 3;38(3):582-597.e6. xingkong星空中国官网: 10.1016/j.cmet.2026.01.008. Epub 2026 Feb 9.PMID: 41666927
200. Qin L, xingkong星空中国官网 Z, Xu Z, Wang X, Tan J, Luo W, Huang K, Yang D, Xiao G, Yi W. Establishment and characterization of a human pre-osteocyte cell line: hOsteo4-E9. JBMR Plus. 2025 Oct 17;10(5):ziaf163. xingkong星空中国官网: 10.1093/jbmrpl/ziaf163. eCollection 2026 May. PMID: 41943818
201. Qin L, Gan D, xingkong星空中国官网 Z, Xu Z, Wu M, Gao B, Long Y, Mou X, Yi W, Xiao G. Mitochondrial transfer in tissue homeostasis and diseases. Int J Biol Sci. 2026 Feb 26;22(6):3144-3173. xingkong星空中国官网: 10.7150/ijbs.129709. eCollection 2026. PMID: 41943850
202. Zou Z, Gong W, Lu X, Zhang Y, Au M, Lin J, Ouyang H, Xiao G, Tang B, Wen C. Endothelin-1/Endothelin B Receptor Signalling Mediates Prx1+ Skeletal Stem Cells Senescence: A Driver of Osteoporotic Bone Loss. J Orthop Translat. 2026 Feb 18;57:101048. xingkong星空中国官网: 10.1016/j.jot.2026.101048. eCollection 2026 Mar. PMID: 41757294
203. xingkong星空中国官网 K, Chen M, Chen C, Yu Y, Shao Z, Cai X, Xiao G, xingkong星空中国官网 S. IFT88/Kindlin-2 signaling prevents mechanical overloading-induced PANoptosis of nucleus pulposus cells by activating FOXP1 SUMOylation. Int J Biol Sci. 2026 Apr 16;22(9):4598-4617. xingkong星空中国官网: 10.7150/ijbs.132842. eCollection 2026. PMID: 42157928
204. Yan Q, Gan D, Xu K, xingkong星空中国官网 Z, Lin S, Zhou B, Xu Z, Zhong Q, Tao C, Zhong Y, Huo S, Yi W, Wang Z, Song X, Qin L, Xiao G. Talin1 loss activates DRG neurons to accelerate bone remodeling and fracture healing in mice. J Orthop Translat. 2026 May 8;58:101113. xingkong星空中国官网: 10.1016/j.jot.2026.101113. eCollection 2026 May. PMID: 42169959 .
205. Qin T, Jiang Y, Xie Y, Qu H, Yan W, Chen J, Chen Y, xingkong星空中国官网 H, Feng N, Wu J, Zhang C, Huang Z, Shi M, Deng Z, Xiao G, Long H. Targeting Dnmt3a/m5C/RelA axis attenuates microglia inflammatory response and improves postoperative recovery in chronic compressive cervical spinal cord injury. Adv Sci (Weinh). 2026 Jun 9:e75995. xingkong星空中国官网: 10.1002/advs.75995. Online ahead of print. PMID: 42261825
206. Gong W, Tao C, Wang X, Liao R, xingkong星空中国官网 J, Guo X, Qu M, Huang J, Chen M, Wei F, Wang P, Lin L, Chen D, Yao Q, Wen C, Xiao G. Sustained HIF-1α Accumulation Disrupts the Articular Niche to Promote Osteoarthritis Pathogenesis. Aging Cell. 2026 Jul;25(7):e70606. xingkong星空中国官网: 10.1111/acel.70606. PMID: 42337938
207. Gan D, Qin L, Xiao G. Inter organ communications in skeletal pathophysiology: from molecular pathways to multidisciplinary therapies. Research (Wash D C). 2026 Jun 24;9:1319. xingkong星空中国官网: 10.34133/research.1319. eCollection 2026.PMID: 42359046
208. Tao C, Lin S, Shi Y, Yang Q, Gong W, Yan Q, Fu X, Gan D, Zhang P, Zou X, Liang C, xingkong星空中国官网 D, Bai X, Wei F, Yao Q, Xiao G. TNF/TNFR inhibits the PTH-Gas axis by Traf2 to promote aging-related bone loss and reduce therapeutic efficacy of PTH1-34 analog in aging skeleton. Innov Med (2026)
Xiao Lab 光荣榜：
Xiaohao Wu, School of Medicine Dean’s Fellowship, Stanford University, $35,000, 2024；
Xiaohao Wu, Stanford Translational and Applied Medicine Pilot Grant, Stanford University, $20,000, 2024.
金小琬，xk星空2024年“艺术优秀奖”研究生
金小琬，xk星空2024年“优秀毕业研究生”
金小琬，xk星空2024年“优秀硕士学位论文”
甘东浩，Postdoc, Yale University, 2024
河泰麟，xk星空2024年研究生“十佳毕业生”（博士研究生）候选人
钟一鸣，首批国家自然科学基金青年学生基础研究项目(博士研究生), 30万, 2024
Talin He，The 5th ICMRC Presidential Award; oral presentation; the highest ranking abstract from about 600 abstracts, 2024
Jiaming Yang，The 5th ICMRC Young Investigator Award, 2024
陈明珏，xk星空医学院第三届“未来之星”论坛，三等奖, 2023
淘楚，xk星空医学系统学术年会，三等奖， 2023
河泰麟，xk星空医学系统学术年会，优秀奖，2023
钟一鸣，博士研究生国家奖学金, 2023
Donghao Gan, ASBMR Young Investigator Award, 2023
Talin He，ICMRS Webster Jee Young Investigator Award, oral presentation, 2023
吴晓昊，Postdoc, Stanford University, 2023
吴晓昊，xk星空2023年研究生“十佳毕业生” (博士研究生)
吴晓昊，xk星空医学院“院长奖”，2023
吴晓昊，2022年“广东省生命健康研究生学术论坛”口头报告一等奖, 2023
Donghao Gan, ICMRS Webster Jee Young Investigator Award, oral presentation, 2023
姚青, 国自然面上基金, 53万，2022
河泰麟，xk星空医学院，优秀博士生，2022
陈明珏，xk星空医学院，优秀研究生，2022
钟一鸣，xk星空医学院“院长奖”，2022
河泰麟，xk星空医学院2021度优秀研究生，2022
钟一鸣，xk星空校级硕士学位论文，2022
钟一鸣，xk星空校级优秀研究生毕业生，2022
钟一鸣，xk星空2022年研究生“十佳毕业生”（硕士研究生）
甘东浩，教育部博士后基金, 8万，2022
Mingjue xingkong星空中国官网, ICMRS Webster Jee Young Investigator Award, oral presentation, 2022
陈明珏，硕士研究生国家奖学金, 2022
吴晓昊，博士研究生国家奖学金, 2022
陈明珏，xk星空医学院第二届“未来之星”论坛，二等奖, 2022
甘东浩，第二届xk星空医疗系统学术年会, 二等奖, 2022
林嗣雄，第二届xk星空医疗系统学术年会, 三等奖，2022
Lei Qin, ASBMR Young Investigator Award, oral presentation,, 2021
曹惠玲, 科技部重大专项, 67万，2021
王依姝，教育部博士后基金, 8万，2021
Xiaohao Wu, ASBMR Felix Bronner Young Investigator Award; the highest ranking abstract from more 1000 abstracts, 2021
钟一鸣 xk星空生命科学学院第二届“学术之星”论坛优秀奖，2021
Xiaohao Wu, ICMRS Webster Jee Young Investigator Award, oral presentation,, 2021
陈明珏，研究生国家奖学金，2021
高焕庆，首届xk星空医学系统学术年会，一等奖， 2021
吴晓昊，首届xk星空医学系统学术年会，三等奖， 2021
陈胜，首届xk星空医学系统学术年会，优秀奖，2021
郭禺熙, 生物系优秀毕业生, 2020
李茹璇, 校十佳毕业生候选人, 校级优秀毕业生, 2020
李鹏宇, 生物系优秀毕业生, 2020
吴晓昊 xk星空生命科学学院首届“学术之星”论坛三等奖，2020
秦雷，教育部博士后基金, 8万，2020
姚青, 深圳市科创委稳定支持，面上项目, 50万，2020
曹惠玲, 国自然面上基金, 55万，2020
曹惠玲, 国自然优秀青年基金获得者, 120万, 2020
Yishu Wang, ASBMR Young Investigator Award, Oral Presentation, 2019
王依姝，博士研究生国家奖学金, 2019
Yiming Lei, ASBMR Education Emerging Country Young Investigator Award，2019
Yiming Lei, ICMRS, Third Young Investigator Prize, oral presentation, 2019
Lei Qin, ICMRS, First Young Investigator Prize, oral presentation, 2019
刘鑫, 校十佳毕业生候选人，校级优秀毕业生, 2019
曹惠玲, 深圳市科创委自由探索基金, 50万，2019
高焕庆, 深圳市科创委基金, 40万，2019
Huiling Cao, ICMRS Webster Jee Travel Award, 2018
Xin Liu, ASBMR Travel Award, Plenary Poster, 2017
Xin Liu, ICMRS, First Young Investigator Prize, oral presentation, 2017
Huiling Cao, ICMRS, First Young Investigator Prize, oral presentation, 2017
Huiling Cao, ASBMR, Plenary Poster, 2017
Huiling Cao, ASBMR Travel Award, Plenary Poster, 2016
曹惠玲, 国自然青年基金, 21.16万，2016