xingkong星空集团官网 Interests
◆Microenvironment, signal transduction and diseases: Cells interact with extra cellular matrix through the forming xingkong星空集团官网-matrix adhesions, which in turn leads to reorganization of actin cytoskeleton and signal transduction. The assembly and disassembly of xingkong星空集团官网-matrix adhesions allow cells to move and are critical for embryonic organ development and postnatal xingkong星空集团官网 function and tissue homeostasis. Conversely, defective control of xingkong星空集团官网-matrix formation is involved in cancer metastasis. The goal of our research is to obtain a detailed understanding of the molecular mechanisms by which the xingkong星空集团官网-matrix adhesion is regulated. We combine xingkong星空集团官网 biology and biochemical approaches to investigate xingkong星空集团官网-adhesion dynamics. Recent interests include the mechanism of assembly, disassembly, and trafficking of adhesion protein complexes that act in regulation of integrin functions. Two protein complexes that emerged from these studies are ILK-PINCH-parvin ternary complex and kindlin-migfilin-filamin complex. ILK-PINCH-parvin complex functions as a signal hub of integrin-mediated signaling by interacting with actin cytoskeleton and many diverse signalling pathways, while kindlin-migfilin-filamin complex play key roles in integrin activation. We use microscopy, including cutting edge fluorescence-based technologies to study questions at different spatial scales.
◆Pancreatic beta-xingkong星空集团官网 biology: The molecular mechanism by which Binding immunoglobulin protein (Bip）acts in protecting human islet amyloid polypeptide (hIAPP) induced beta-xingkong星空集团官网 damage.

Professional Experience
◆ 2020-present: Teaching Professor,Department of Biology, Southern University of Science and Technology of China
◆ 2012-2019: Associate Professor, Department of Biology, Southern University of Science and Technology of China
◆ 2011-2012: xingkong星空集团官网 Associate The Chinese University of Hong Kong
◆ 2009-2011: xingkong星空集团官网 Associate The University of Science and Technology of Hong Kong
◆ 2003-2008: Postdoctoral Fellow National Institutes of Health (NIH, USA)

Educational Background
◆ PhD Department of Biology Ruhr-University Bochum (Germany) 2002
◆ MS Department of Biology Shandong University 1999
◆ BS Department of Biology Shandong University 1996

Selected Publication
1. Liu Z, Kwan T, Cheng, Shi Z, Liu Z, Lei Y, Wang C, Shi W, Chen X, Qi X, Cai D, Feng B, xingkong星空集团官网 Y*, Chen C and Zhao H. Efficient genome editing of genes involved in neural crest development using the CRISPR/Cas9 system in Xenopus embryos . Cell Biosci (2016) 6:22.
2. Wang C, Kam RK, Shi W, Xia Y, Chen X, Cao Y, Sun J, Du Y, Lu G, Chen Z, Chan WY, Chan SO, xingkong星空集团官网 Y*, Zhao H. The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling. J Biol Chem. (2015) 290: 21925.
3. Shi W, Xu G, Wang C, Sperber SM, Chen Y, Zhou Q, xingkong星空集团官网 Y*, Zhao H*. Heat Shock 70-kDa Protein 5 (Hspa5) Is Essential for Pronephros Formation by Mediating Retinoic Acid Signaling.J Biol Chem. (2015) 290:577. (* co-corresponding author)
4. Lei Y, Guo X, xingkong星空集团官网 Y, Chen Y, Zhao H Generation of gene disruptions by transcription activator-like effector nucleases (TALENs) in Xenopus tropicalis embryos. Cell Biosci. (2013) 3: 21.
5. Kang ZF, xingkong星空集团官网 Y, Zhou Y, Fan RR, Chan JC, Laybutt DR, Luzuriaga J, Xu G. Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes. Diabetologia(2013) 56: 423.
6. Lei Y, Guo X, Liu Y, Cao Y, Deng Y, Chen X, Cheng xingkong星空集团官网, Dawid IB, Chen Y, Zhao H. Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc Natl Acad Sci U S A. (2012) 109: 17484.
7. Kam RK, xingkong星空集团官网, Y, Chen Y, Zhao H. Retinoic acid synthesis and functions in early embryonic development.Cell Biosci. (2012) 2: 11.
8. xingkong星空集团官网 Y*, Guo Y*, Watson H, Au WC, Shakoury-Elizeh M, Basrai MA, Bonifacino JS, Philpott CC. GGA2 mediates sequential ubiquitin-independent and -dependent steps in the trafficking of ARN1 from the trans-golgi network to the vacuole. J Biol Chem (2009) 284: 23830-23841. (* co-first author)
9. xingkong星空集团官网 Y*, Golinelli-Cohen M*, Smirnova E, and Jackson CL. A COPI coat subunit interacts directly with an early-Golgi localized Arf Exchange Factor. EMBO Rep (2009) 10: 58-64. (* co-first author)
10. Kim Y*, xingkong星空集团官网 Y*, Philpott CC. GGA2- and Ubiquitin-dependent Trafficking of Arn1, the Ferrichrome Transporter of Saccharomyces cerevisiae. Mol Biol Cell (2007) 18: 1790-1802. (* co-first author)
11. xingkong星空集团官网 Y, Schmidtmann A, Kruse S, Filatov V, Heilmeyer LM Jr, Jaquet K Thieleczek R. Phosphorylation of human cardiac troponin I G203S and K206Qlinked to familial hypertrophic cardiomyopathy affects actomyosin interaction in different ways. J Mol Cell Cardiol (2003) 35: 1365-1374.
12. xingkong星空集团官网 Y, Schmidtmann A., Redlich A., Westerdorf B., Jaquet K, Thieleczek R. Effects of Phosphorylation and Mutation R145G on Human Cardiac Troponin I Function. Biochemistry (2001) 40: 14593-14602.