Self-introduction：

I obtained my Ph.D. from The Chinese University of Hong Kong and am currently serving as an Assistant Professor in the Department of Basic Immunology and Microbiology at the Southern University of Science and Technology. Over the past few years, I have published many academic articles in reputable international journals, including Brief in Bioinformatics, Oncogene, and Cancer Research. My research is focused on exploring genome evolution, understanding transcriptional regulatory mechanisms, and investigating tumor metabolism through the analysis of multi-omics data.

Research Interests：

◆Genome Evolution;

◆Tumor Metabolism;

◆Transcriptional Regulatory Mechanisms.

Professional Experience：

◆ 2023 - Present  Assistant Professor,  Southern University of Science and Technology

◆ 2021 - 2023      Postdoctoral Researcher ,  Southern University of Science and Technology

◆ 2020 - 2021      Chief Scientist,   Cytomics  Limited

◆ 2019 - 2020      Postdoctoral Researcher,  The Chinese University of Hong Kong

◆ 2013 - 2014      Research Assistant,  Shenzhen Research Institute,  The Chinese University of Hong Kong

Educational Background：

◆ 2014 - 2018      The Chinese University of Hong Kong,  Ph.D. in Chemical Pathology

◆ 2008 - 2013      Harbin Medical University,  Bachelor's degree in Bioinformatics

Selected Publication：

1. Pan Y, Chen H, Zhang X, Liu W, Ding Y, xk星空官网 D, Zhai J, Wei W, Wen J, Chen D, Zhou Y, Liang C, Wong N, Man K, Cheung AH, Wong CC, Yu J. METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy. Cell Rep Med. 2023 Aug 15;4(8):101144. doi: 10.1016/j.xcrm.2023.101144. PMID: 37586322; PMCID: PMC10439254. 

2. xk星空官网 Q, Chan H, Liu WX, Liu CA, Zhou Y, xk星空官网 D. ... & Yu J. Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice. Cancer Cell. 2023 Jul 14:S1535-6108(23)00236-2. doi: 10.1016/j.ccell.2023.06.011.

3. Bao Y, Zhai J, Chen H, Wong C, Liang C, Ding Y, xk星空官网 D. ... & Yu, J.Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer.Gut 2023;72:1497-1509.

4. Chen, H., Pan, Y., Zhou, Q., Liang, C., Wong, C. C., Zhou, Y.,xk星空官网, D. ... & Yu, J. (2022). METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer. Gastroenterology. 

5. Zhou Z, xk星空官网 F, xk星空官网 D, Chi Q, Tang NLS. Nonsense-Mediated Decay Targeted RNA (ntRNA): Proposal of a ntRNA-miRNA-lncRNA Triple Regulatory Network Usable as Biomarker of Prognostic Risk in Patients with Kidney Cancer. Genes (Basel). 2022 Sep 15;13(9):1656. doi: 10.3390/genes13091656.

6. xk星空官网, D.*, Wang, X.*., xk星空官网, Z., Liu, Y., Liu, X., Gin, T., ... & Wu, W. K. K. (2022). 3′ untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance. Oncogene, 1-11.

7. Wang, X., xk星空官网, W., Li, X., Huang, D., Li, Q., Chan, H., Zeng, J., Xie, C., Chen, H., Liu, X. and Gin, T., 2022. Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution. Cancer Research, 82(8), pp.1482-1491. 

8. xk星空官网, X., Cheng, F.T., Lam, T.Y., Liu, Y., xk星空官网, D., Liu, X., Chen, H., Zhang, L., Ali, Y., xk星空官网, M.H. and Yu, J., 2022. Stress Hyperglycemia Is Associated With an Increased Risk of Subsequent Development of Diabetes Among Bacteremic and Nonbacteremic Patients. Diabetes Care. 

9. Liu Y, Ling L, Wong SH, Wang MH, Fitzgerald JR, Zou X, Fang S, Liu X, Wang X, xk星空官网 W, Chan H, Wang Y, xk星空官网 D, xk星空官网 Q, Wong WT, Choi G, Zou H, Hui DS, Yu J, Tse G, Gin T, Wu WK, Chan MT, Zhang L. Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients. EClinicalMedicine. 2021 Jun 10;37:100955. doi: 10.1016/j.eclinm.2021.100955. PMID: 34386745; PMCID: PMC8343259. 

10. xk星空官网, D*., Wang, X*., Liu, Y., Huang, Z., xk星空官网, X., xk星空官网, W., Li, Q., Chan, H., Zou, Y., Ho, I.H. and Wang, Y., 2021. Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance. Briefings in Bioinformatics, 22(5), p.bbab040.

11. xk星空官网, D., Liu, A.Y., Leung, K.S. and Tang, N.L., 2021. Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine Seroconversion. Genes, 12(7), p.971.

12. Ma SL, Wu J, Zhu L, xk星空官网 RS, Wang X, xk星空官网 D, Tang NL, Woo J. Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia. Nutrients. 2021 Jul 5;13(7):2313. doi: 10.3390/nu13072313. PMID: 34371826; PMCID: PMC8308783. 

13. Li, Q., xk星空官网, W., Liu, W.X., Zhao, L.Y., xk星空官网, D., Liu, X.D., xk星空官网, H., Zhang, Y., Zeng, J.D., Coker, O.O. and Kang, W., 2020. Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase. Gastroenterology .

14. Lee, K.Y., Leung, K.S., Ma, S.L., So, H.C., xk星空官网, D., Tang, N.L.S. and Wong, M.H., 2020. Genome-Wide Search for SNP Interactions in GWAS Data: Algorithm, Feasibility, Replication Using Schizophrenia Datasets. Frontiers in genetics, 11.

15. Ji, L., Wu, D., Xie, H., Yao, B., Chen, Y., Irwin, D.M., xk星空官网, D., Xu, J., Tang, N.L. and Zhang, Y., 2020. Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity. Genomics, Proteomics & Bioinformatics .

16. Tang, N.L.S., Hui, J., xk星空官网, D., Tang, M.F., Wang, X., Wu, J., xk星空官网, I.H. and Leung, T.F., 2020. Reference intervals of spot urine copper excretion in preschool children and potential application in pre-symptomatic screening of Wilson disease. Pathology, 52(4), pp.439-446.

17. Tang NL, Wang X, Chang KC, xk星空官网 CY, Szeto NW, xk星空官网 D, Wu J, Lui GC, Leung CC, Hui M. Genetic susceptibility to Tuberculosis: Interaction between HLA-DQA1 and age of onset. Infection, Genetics and Evolution. 2019 Mar 1;68:98-104 .

18. Wu D, Kang J, Huang Y, xk星空官网 X, Wang X, xk星空官网 D, Wang Y, xk星空官网 B, Hao D, Gu Q, Tang N. Deciphering global signal features of high-throughput array data from cancers. Molecular BioSystems. 2014;10(6):1549-56.